Persisting high levels of synovial fluid markers after cartilage repair: a pilot study.

Clinical Orthopaedics and Related Research
Anna I VasaraIlkka Kiviranta

Abstract

Local attempts to repair a cartilage lesion could cause increased levels of anabolic and catabolic factors in the synovial fluid. After repair with regenerated cartilage, the homeostasis of the cartilage ideally would return to normal. In this pilot study, we first hypothesized levels of synovial fluid markers would be higher in patients with cartilage lesions than in patients with no cartilage lesions, and then we hypothesized the levels of synovial fluid markers would decrease after cartilage repair. We collected synovial fluid samples from 10 patients before autologous chondrocyte transplantation of the knee. One year later, a second set of samples was collected and arthroscopic evaluation of the repair site was performed. Fifteen patients undergoing knee arthroscopy for various symptoms but with no apparent cartilage lesions served as control subjects. We measured synovial fluid matrix metalloproteinase-3 (MMP-3) and insulinlike growth factor-I (IGF-I) concentrations with specific activity and enzyme-linked immunosorbent assays, respectively. The levels of MMP-3 and IGF-I were higher in patients having cartilage lesions than in control subjects with no cartilage lesions. One year after cartilage repair, the lesions were fil...Continue Reading

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Citations

Dec 17, 2011·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Andras HeijinkC Niek Van Dijk
Mar 25, 2014·European Journal of Orthopaedic Surgery & Traumatology : Orthopédie Traumatologie·Hagen SchmalPhilipp Niemeyer
May 21, 2009·Journal of Cellular and Molecular Medicine·Gerjo J V M van OschFrank P Luyten
Apr 19, 2013·Revista española de cirugía ortopédica y traumatología·P Martínez de Albornoz Torrente, F Forriol

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