Personality and Incident Alzheimer's Disease: Theory, Evidence, and Future Directions

The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
Suzanne C Segerstrom

Abstract

Personality, especially the dimensions of neuroticism and conscientiousness, has prospectively predicted the risk of incident Alzheimer's disease (AD). Such a relationship could be explained by personality and AD risk having a common cause such as a gene; by personality creating a predisposition for AD through health behavior or inflammation; by personality exerting a pathoplastic effect on the cognitive consequences of neuropathology; or by AD and personality change existing on a disease spectrum that begins up to decades before diagnosis. Using the 5-dimensional taxonomy of personality, the present review describes how these models might arise, the evidence for each, and how they might be distinguished from one another empirically. At present, the evidence is sparse but tends to suggest predisposition and/or pathoplastic relationships. Future studies using noninvasive assessment of neuropathology are needed to distinguish these 2 possibilities.

References

Jan 1, 1992·European Archives of Psychiatry and Clinical Neuroscience·O HagnellB Rorsman
Apr 1, 1995·Journal of Personality and Social Psychology·H S FriedmanM H Criqui
Sep 1, 1994·Journal of Personality·S Booth-Kewley, R R Vickers
Aug 1, 1997·Journal of Surgical Oncology·S Friberg, S Mattson
Jun 20, 2000·Neurobiology of Aging·H AkiyamaT Wyss-Coray
Mar 5, 2005·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Steve BalsisMartha Storandt
Oct 14, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kristen L BrunsonTallie Z Baram
Jul 25, 2006·Personality & Social Psychology Bulletin·Antonio TerraccianoRobert R McCrae
Jan 11, 2007·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·Sarah E HampsonJoan P Dubanoski
Sep 14, 2007·Journal of Alzheimer's Disease : JAD·Laura Fratiglioni, Hui-Xin Wang
Oct 3, 2007·Archives of General Psychiatry·Robert S WilsonDavid A Bennett
Dec 15, 2007·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Janet M DuchekRandy Larsen
Jan 21, 2009·Neurology·H-X WangL Fratiglioni
May 20, 2009·The American Psychologist·Benjamin B Lahey
Jan 20, 2010·Lancet Neurology·Clifford R JackJohn Q Trojanowski
Nov 9, 2010·Personality and Individual Differences·Andrea Soubelet, Timothy Salthouse
Mar 23, 2011·Psychology and Aging·Ulman LindenbergerChristopher Hertzog
Jul 22, 2011·Lancet Neurology·Deborah E Barnes, Kristine Yaffe
Sep 10, 2011·International Journal of Geriatric Psychiatry·Tarja-Brita Robins Wahlin, Gerard J Byrne
Jul 13, 2012·The New England Journal of Medicine·Randall J BatemanUNKNOWN Dominantly Inherited Alzheimer Network
Sep 8, 2012·Psychological Medicine·I H G B RamakersUNKNOWN Alzheimer's Disease Neuroimaging Initiative and DESCRIPA Investigators
Oct 9, 2012·Neurobiology of Aging·Antonio TerraccianoSusan M Resnick
Oct 20, 2012·Lancet Neurology·Yaakov Stern
Oct 20, 2012·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Ilan Dar-NimrodPaul R Duberstein
Nov 6, 2012·Brain, Behavior, and Immunity·Nicholas A TurianoBenjamin P Chapman
May 28, 2013·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Antonio TerraccianoSusan M Resnick
Aug 6, 2013·American Journal of Epidemiology·Markus JokelaMika Kivimäki
Dec 25, 2013·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·Nicholas A TurianoDaniel K Mroczek
Jan 24, 2014·The New England Journal of Medicine·Rachelle S DoodyUNKNOWN Solanezumab Study Group
Jan 24, 2014·The New England Journal of Medicine·Stephen SallowayUNKNOWN Bapineuzumab 301 and 302 Clinical Trial Investigators
Jun 3, 2014·BMC Neuroscience·Christian MontagMartin Reuter
Sep 19, 2014·Psychoneuroendocrinology·Martina LuchettiAngelina R Sutin
Mar 10, 2015·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Beth E SnitzWilliam E Klunk
May 12, 2015·Psychological Bulletin·Tena Vukasović, Denis Bratko
Dec 1, 2007·Perspectives on Psychological Science : a Journal of the Association for Psychological Science·Brent W RobertsLewis R Goldberg

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Citations

Dec 14, 2019·The Journal of General Psychology·Joana Henriques-Calado, Maria Eugénia Duarte-Silva
Dec 7, 2019·BMC Geriatrics·Angelina R SutinAntonio Terracciano
May 16, 2019·Neural Regeneration Research·Edwin E Reza-ZaldivarAlejandro A Canales-Aguirre
Apr 30, 2019·Journal of Aging and Health·Angelina R SutinAntonio Terracciano
Sep 25, 2020·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Eileen K GrahamDaniel K Mroczek
Sep 9, 2020·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Yannick StephanAntonio Terracciano
Jan 20, 2021·Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition·Angelina R SutinAntonio Terracciano
Nov 19, 2020·Journal of Geriatric Psychiatry and Neurology·Anastasia BougeaGeorge Chrousos
Jul 6, 2021·European Journal of Ageing·Cornelia PocnetDaniela Jopp
Jul 31, 2021·GeroPsych·Damaris AschwandenAntonio Terracciano
Aug 31, 2021·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Amanda A SeskerAngelina R Sutin

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