Personality characteristics and hypothalamic-pituitary-adrenal axis regulation in older persons

The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry
L GerritsenH C Comijs

Abstract

To investigate the cross-sectional association between personality characteristics and hypothalamic-pituitary-adrenal (HPA) axis regulation in older persons. The study sample consisted of 1,150 participants (mean age 74.8 +/- 7.1 years, 48% male) from the population-based Longitudinal Aging Study Amsterdam. HPA axis activity was measured with salivary cortisol collected after awakening and late in the evening. Outcome measures were awakening and evening cortisol levels (natural log transformed) and the diurnal pattern of cortisol. Determinants were scores on questionnaires assessing neuroticism, mastery, and self-esteem. Multiple linear regression analyses adjusted for potential confounders did not show significant associations between any of the personality characteristics and any of the cortisol measures. On evening cortisol, a significant interaction was observed between neuroticism and age (B = -0.001; T = -2.50, df = 1,139; p value = 0.01). After stratification in two age groups, the authors observed that high levels of neuroticism were associated with elevated levels of evening cortisol in subjects aged <75 years (B = 0.02; 95% confidence interval: 0.01-0.03; T = 2.15, df = 630, p = 0.03) but not in subjects aged 75 years...Continue Reading

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Citations

May 4, 2011·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·Susan K Roepke, Igor Grant
May 9, 2012·Psychological Medicine·J Herbert
Dec 24, 2013·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Gloria Garcia-BandaPhil Evans
Oct 17, 2012·Neuroscience and Biobehavioral Reviews·Johan OrmelAndré Aleman
Sep 3, 2010·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Marcellus M MerrittThomas Fritsch
Mar 18, 2016·Psychoneuroendocrinology·Karissa G MillerStephen B Manuck
Jun 23, 2016·International Journal of Geriatric Psychiatry·Ruth KlamingHannie C Comijs
Oct 4, 2011·Journal of Clinical Psychology in Medical Settings·María Pilar MartínezMaría José Lami
Mar 19, 2019·Frontiers in Aging Neuroscience·Sami Ouanes, Julius Popp
May 20, 2020·Psychosomatic Medicine·Kristina D DickmanThomas W Kamarck
Jun 26, 2020·Frontiers in Psychology·Teresa MontoliuAlicia Salvador

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