Personality traits and behavioral and psychological symptoms in patients at an early stage of Alzheimer's disease

International Journal of Geriatric Psychiatry
Cornelia PocnetArmin von Gunten

Abstract

The origins of behavioral and psychological symptoms (BPS) in Alzheimer's disease (AD) are still poorly understood. Focusing on individual personality structure, we explored the relationship between premorbid personality and its changes over 5 years, and BPS in patients at an early stage of AD. A total of 54 patients at an early stage of AD according to ICD-10 and NINCDS-ADRDA criteria and 64 control subjects were included. Family members filled in the Neuropsychiatric Inventory Questionnaire to evaluate their proxies' current BPS and the NEO Personality Inventory Revised twice, the first time to evaluate the participants' current personality and the second time to assess personality traits as they were remembered to be 5 years earlier. Behavioral and psychological symptoms, in particular apathy, depression, anxiety, and agitation, are frequent occurrences in early stage AD. Premorbid personality differed between AD patients and normal control, but it was not predictive of BPS in patients with AD. Personality traits clearly change in the course of beginning AD, and this change seems to develop in parallel with BPS as early signs of AD. Premorbid personality was not associated with BPS in early stage of AD, although complex and ...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
May 1, 1992·Archives of Neurology·A ChatterjeeP J Whitehouse
Jun 1, 1991·Archives of Neurology·G S ZubenkoU Kopp
Jan 1, 1987·Journal of Personality and Social Psychology·R R McCrae, P T Costa
Jun 1, 1983·Acta Psychiatrica Scandinavica·A S Zigmond, R P Snaith
Jan 1, 1996·Image--the Journal of Nursing Scholarship·A M Kolanowski, A L Whall
Mar 1, 1997·Archives of Neurology·M E StraussJ M DiFilippo
Feb 1, 1997·Journal of Gerontological Nursing·A M KolanowskiA Whall
Sep 11, 1998·International Journal of Geriatric Psychiatry·J BrandtC Lyketsos
Jul 9, 1999·The British Journal of Medical Psychology·R Cheston, M Bender
Nov 5, 1999·International Psychogeriatrics·L AitkenA Burns
Jan 14, 2000·The Journal of Neuroscience Nursing : Journal of the American Association of Neuroscience Nurses·A M Kolanowski, M Garr
Sep 5, 2002·International Journal of Geriatric Psychiatry·Lee-Fay LowBrian Draper
Nov 12, 2002·Aging & Mental Health·N PurandareA Burns
Mar 12, 2004·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·David W GilleyDenis A Evans
Mar 5, 2005·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Steve BalsisMartha Storandt
Feb 27, 2007·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Nicola ArcherSimon Lovestone
Dec 15, 2007·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Janet M DuchekRandy Larsen
Jun 20, 2008·Scandinavian Journal of Psychology·Hanna Li Kusterer
Sep 20, 2008·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Jérôme RossierUNKNOWN Personality Across Culture Research Group
Nov 26, 2008·Archives of Psychiatric Nursing·Jun-Ah Song, Donna Algase
Aug 13, 2011·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Cornelia PocnetArmin von Gunten
Jan 1, 2009·Language Learning and Development : the Official Journal of the Society for Language Development·Daniel J WeissAaron D Mitchel

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Citations

Mar 4, 2015·Wiener klinische Wochenschrift·Johann LehrnerGisela Pusswald
May 1, 2016·Neurología : publicación oficial de la Sociedad Española de Neurología·A Pérez Romero, S González Garrido
Jul 17, 2013·Journal of Geriatric Psychiatry and Neurology·Sharpley HsiehOlivier Piguet
Jan 18, 2018·Journal of the American Geriatrics Society·Richard J CaselliDona E C Locke
Oct 19, 2017·Journal of Alzheimer's Disease : JAD·Aditi JoshiMario F Mendez
Apr 19, 2019·Neurodegenerative Disease Management·Juan J YoungRajesh R Tampi
Jun 4, 2019·Journal of Alzheimer's Disease : JAD·Isabelle RouchPierre Krolak-Salmon
Jun 20, 2015·Journal of Movement Disorders·Hye Mi Lee, Seong-Beom Koh
Feb 19, 2020·Current Topics in Medicinal Chemistry·Valérie ZuffereyFerath Kherif
Sep 17, 2019·Journal of Alzheimer's Disease : JAD·Isabelle RouchPierre Krolak-Salmon
Jan 3, 2020·International Journal of Geriatric Psychiatry·Anna SzücsAlexandre Y Dombrovski
Jan 28, 2020·Journal of Alzheimer's Disease : JAD·Jean-Michel DoreyPierre Krolak-Salmon
May 18, 2020·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Silvia Rios-RomenetsUNKNOWN the API ADAD Colombia Trial Group
Aug 7, 2017·Therapeutic Advances in Neurological Disorders·Olivier Pierre TibleArmin von Gunten
Jun 27, 2020·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Andrew J AschenbrennerUNKNOWN Dominantly Inherited Alzheimer Network
May 14, 2021·JAD Reports·Mario F Mendez
Jan 12, 2019·Journal of the American Medical Directors Association·Maheen IslamAntonio Terracciano

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