Personalization of prostate cancer therapy through phosphoproteomics

Nature Reviews. Urology
Wei YangNatasha Kyprianou

Abstract

Castration-resistant prostate cancer (CRPC) remains incurable despite the approval of several new treatments. Identification of new biomarkers and therapeutic targets to enable personalization of CRPC therapy, with the aim of maximizing therapeutic responses and minimizing toxicity in patients, is urgently needed. Prostate cancer progression and therapeutic resistance are frequently driven by aberrantly activated kinase signalling pathways that are amenable to pharmacological inhibition. Personalized phosphoproteomics, which enables the analysis of signalling networks in individual tumours, is a promising approach to advance personalized therapy by discovering biomarkers of pathway activity and clinically actionable targets. Several technologies for global and targeted phosphoproteomic analysis exist, each with its own strengths and shortcomings. Global discovery phosphoproteomics is predominantly conducted using liquid chromatography-tandem mass spectrometry coupled with data-dependent or data-independent acquisition technologies. Multiplexed targeted phosphoproteomics can be divided into platforms based on mass spectrometry or antibodies, including selected or parallel reaction monitoring and triggered by offset, multiplexed,...Continue Reading

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Citations

Aug 15, 2019·Bioinformatics·Hongyang Li, Yuanfang Guan
Jun 29, 2018·International Journal of Molecular Sciences·Camilla EvangelistiAlberto M Martelli
Jul 31, 2020·Computational and Structural Biotechnology Journal·Gonzalo Pérez-MejíasIrene Díaz-Moreno
Mar 22, 2021·Cardiovascular Research·Sina SafabakhshZachary Laksman
Aug 11, 2021·Laboratory Investigation; a Journal of Technical Methods and Pathology·Shaobin WuDazun Shi

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Methods Mentioned

BETA
transcriptomic profiling
glycosylation
acetylation
protein array
xenograft
xenografts
biopsy
dot-blot
antibody array
biopsies

Clinical Trials Mentioned

NCT02799602
NCT02438007

Software Mentioned

Cytoscape
TOMAHAQ
DeMix
MaxLFQ
EasyPhos
Omics Integrator
PHOTON

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