"Personalized Cancer Therapy": A Publicly Available Precision Oncology Resource

Cancer Research
Katherine C KurnitFunda Meric-Bernstam

Abstract

High-throughput genomic and molecular profiling of tumors is emerging as an important clinical approach. Molecular profiling is increasingly being used to guide cancer patient care, especially in advanced and incurable cancers. However, navigating the scientific literature to make evidence-based clinical decisions based on molecular profiling results is overwhelming for many oncology clinicians and researchers. The Personalized Cancer Therapy website (www.personalizedcancertherapy.org) was created to provide an online resource for clinicians and researchers to facilitate navigation of available data. Specifically, this resource can be used to help identify potential therapy options for patients harboring oncogenic genomic alterations. Herein, we describe how content on www.personalizedcancertherapy.org is generated and maintained. We end with case scenarios to illustrate the clinical utility of the website. The goal of this publicly available resource is to provide easily accessible information to a broad oncology audience, as this may help ease the information retrieval burden facing participants in the precision oncology field. Cancer Res; 77(21); e123-6. ©2017 AACR.

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Citations

Dec 8, 2017·Cold Spring Harbor Molecular Case Studies·Ecaterina Ileana Dumbrava, Funda Meric-Bernstam
May 25, 2018·Expert Opinion on Drug Discovery·Ecaterina Ileana DumbravaTimothy A Yap
May 1, 2019·Der Pathologe·S Merkelbach-BruseF Klauschen
Jun 26, 2018·Briefings in Bioinformatics·Mikhail G Dozmorov
Apr 18, 2019·Annual Review of Genomics and Human Genetics·Kenna R Mills Shaw, Anirban Maitra
Mar 3, 2020·Frontiers in Cell and Developmental Biology·Xuanyi Li, Jeremy L Warner
Apr 27, 2018·BMC Medical Genomics·Jennifer D HintzscheAik Choon Tan
Dec 3, 2017·Cancer Discovery·John H StricklerScott Kopetz
Dec 21, 2021·Briefings in Bioinformatics·Dan ShaoJing Zhao

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