Personalized epigenetic management of diabetes

Personalized Medicine
Adriana FodorEddy Karnieli

Abstract

Epigenetic regulation of gene expression allows the organism to respond/adapt to environmental conditions without changing the gene coding sequence. Epigenetic modifications have also been found to control gene expression in various diseases, including diabetes. Epigenetic changes induced by hyperglycemia in multiple target organs contribute to metabolic memory of diabetic complications. The long-lasting development of diabetic complications even after achieving glucose control has been partly attributed to epigenetic changes in target cells. Specific epigenetic drugs might rescue chromatin conformation associated to hyperglycemia possibly slowing down the onset of diabetes-related complications. The current review will describe the updated epigenetics in diabetes that can be used to personalize a more focused treatment.

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Citations

Jul 27, 2017·Clinical and Translational Medicine·Enrico Capobianco
May 27, 2016·Hormone Molecular Biology and Clinical Investigation·Changhu LeeJiyoung Park
Sep 1, 2016·Personalized Medicine·Adriana Fodor, Eddy Karnieli
May 12, 2018·Personalized Medicine·Adriana FodorEddy Karnieli
Aug 29, 2019·Drug Metabolism Reviews·Adriana FodorGabriela Roman
Mar 4, 2021·Ageing Research Reviews·Elena G PasyukovaAlexander M Vaiserman

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Methods Mentioned

BETA
sumoylation
acetylation
histone acetylation
PCR

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