Personalized extended interval dosing of natalizumab in MS- a prospective multicenter trial

Neurology
Z L E van KempenJ Killestein

Abstract

We aimed to determine whether natalizumab efficacy is maintained when switching to personalized extended interval dosing based on individual natalizumab trough concentrations in relapsing remitting MS patients. This was a prospective multicenter single-arm trial with one year follow-up and a one year extension phase. Participants were adult persons with MS treated with natalizumab without disease activity in the year prior to enrollment. The natalizumab treatment interval was based on longitudinal natalizumab trough concentrations. Patients received three monthly MRI scans, relapse assessments and disability scoring during follow-up. The primary endpoint was the occurrence of gadolinium enhancing lesions on MRI. Secondary endpoints were new/enlarging T2 lesions on MRI, relapses and progression on the Expanded Disability Status Scale (EDSS) during follow-up and extension phase. Sixty-one patients were included. Eighty-four percent extended the interval from a 4-week interval to a 5-7-week interval. No patient developed gadolinium enhancing lesions (95% CI 0 - 7.4%) during follow-up. No new/enlarging T2 lesions (95% CI 0 - 7.4%) or relapses (95% CI 0 - 7.4%) were reported during follow-up and in the extension phase. Median EDSS w...Continue Reading

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Sep 26, 2019·Neurology·Zoé L E van KempenJoep Killestein

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Citations

Mar 27, 2021·Journal of the Neurological Sciences·Stefania Federica De MercantiMarinella Clerico
Apr 13, 2021·Current Opinion in Neurology·Klaus SchmiererDavid Baker
May 15, 2021·Multiple Sclerosis and Related Disorders·E M E CoerverE M M Strijbis
Jul 22, 2021·Annals of Clinical and Translational Neurology·Timothy J SchultzJanakan Ravindran
Jul 10, 2021·Multiple Sclerosis : Clinical and Laboratory Research·Zoë Ygj van LieropZoé LE van Kempen

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