Personalized medicine: a competitor or an upgrade of evidence-based medicine?

Personalized Medicine
Daniel Bereczki

Abstract

Evidence-based medicine is a method of healthcare decision-making that intends to combine the most reliable scientific information with individual expertise and patient preferences in order to offer the optimal diagnostic and therapeutic option for the patient. In recent years, the term personalized medicine has been introduced to represent an approach considering differences among individual patients. In modern medicine the most important sources of evidence are clinical trials using epidemiological methods, and molecular biological and genetic methods characterizing individual patients. Responses to a certain therapeutic intervention differ among patients for several reasons. Identifying benefits and harms of an intervention can be handled by two approaches. The first is a statistical approach using the rule of large numbers, resulting in statistically meaningful conclusions. The other approach is personalized: the conclusions are valid for individual patients or subgroups identified by well-defined markers. Whether the evidence is statistical deriving from a large number of clinical observations or personalized based on molecular studies - it should be scientifically sound to apply in clinical practice. Confronting evidence-...Continue Reading

References

Nov 4, 1992·JAMA : the Journal of the American Medical Association·UNKNOWN Evidence-Based Medicine Working Group
Oct 1, 1971·Postgraduate Medical Journal·J K Huttunen
Jan 13, 1996·BMJ : British Medical Journal·D L SackettW S Richardson
Aug 13, 1998·Archives of Internal Medicine·G MichaudP Tugwell
Feb 29, 2000·Journal of the Royal Society of Medicine·A J de CraenJ Kleijnen
Sep 2, 2000·Journal of Evaluation in Clinical Practice·S Buetow, T Kenealy
May 2, 2001·Journal of Health Politics, Policy and Law·C D Mulrow, K N Lohr
Jul 28, 1962·British Medical Journal·D H WOOLLAM
Feb 9, 1952·British Medical Journal·D M DUNLOPR S INCH
Sep 24, 2004·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M BraininUNKNOWN Guideline Standards Subcommittee of the EFNS Scientific Committee
Jan 14, 2005·Health Affairs·Stefan Timmermans, Aaron Mauck
Mar 22, 2005·Journal of Clinical Pharmacology·Cedric M Smith
Aug 16, 2006·Journal of Evaluation in Clinical Practice·Milos Jenicek
Nov 21, 2008·Journal of Evaluation in Clinical Practice·Andrew MilesAndreas Polychronis
Feb 20, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·William R MillerJ Michael Dixon
May 23, 2009·The Oncologist·Jan Trøst Jørgensen
Nov 26, 2009·Translational Research : the Journal of Laboratory and Clinical Medicine·Jeffrey Laurence
Nov 26, 2009·Translational Research : the Journal of Laboratory and Clinical Medicine·Geoffrey S Ginsburg, Huntington F Willard
Jan 13, 2010·Nature Reviews. Genetics·Alan E GuttmacherKári Stefánsson
Feb 23, 2010·Trends in Biochemical Sciences·Donald A McClain
Mar 6, 2010·Blood·Nita A LimdiUNKNOWN International Warfarin Pharmacogenetics Consortium
May 14, 2010·The Journal of Investigative Dermatology·Heidi H Kong, Julia A Segre
May 21, 2010·Clinical Pharmacology and Therapeutics·M J Khoury
Jun 22, 2010·Asian Journal of Andrology·Wen-Bing ZhuLi-Qing Fan
Aug 12, 2010·Nature Reviews. Clinical Oncology·Sandip Basu
Nov 12, 2010·Annals of the Rheumatic Diseases·John D Isaacs, Gianfranco Ferraccioli
Dec 15, 2010·Future Cardiology·Giuseppe Tarantini, Davide Lanzellotti
Feb 25, 2011·Breast Cancer Research : BCR·Charles SwantonP Andrew Futreal
Mar 3, 2011·International Journal of Clinical Pharmacy·Bob WilffertUNKNOWN KNMP working group Pharmacogenetics
Apr 6, 2011·Implementation Science : IS·Katherine KahnHarold Pincus
Apr 19, 2011·The Journal of Molecular Diagnostics : JMD·UNKNOWN AMP Whole Genome Analysis Working Group
Apr 21, 2011·Human Genetics·Angus Clarke, Katie Thirlaway
May 20, 2011·Current Cardiology Reports·Elise CamilleriLaurent Bonello
Jun 29, 2011·Disease Models & Mechanisms·Linda L Restifo, Gerald R Phelan
Jul 5, 2011·Annual Review of Genomics and Human Genetics·Isaac S Chan, Geoffrey S Ginsburg
Jul 20, 2011·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·George BrowmanNoni E MacDonald
Jul 21, 2011·Molecular Oncology·Janet Fricker
Jul 26, 2011·Annals of the Rheumatic Diseases·P MiossecUNKNOWN Group for Respect of Ethics and Excellence in Science (GREES)
Jul 30, 2011·BMJ : British Medical Journal·Morris J Brown

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Citations

Apr 15, 2020·Nutrition Reviews·Michelle BarrowCelia Bell
Nov 28, 2012·New Biotechnology·Ayşe Yüzbaşıoğlu, Meral Özgüç

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