Personalized medicine for patients with COPD: where are we?

International Journal of Chronic Obstructive Pulmonary Disease
Frits Me FranssenBernd Schmeck

Abstract

Chronic airflow limitation is the common denominator of patients with chronic obstructive pulmonary disease (COPD). However, it is not possible to predict morbidity and mortality of individual patients based on the degree of lung function impairment, nor does the degree of airflow limitation allow guidance regarding therapies. Over the last decades, understanding of the factors contributing to the heterogeneity of disease trajectories, clinical presentation, and response to existing therapies has greatly advanced. Indeed, diagnostic assessment and treatment algorithms for COPD have become more personalized. In addition to the pulmonary abnormalities and inhaler therapies, extra-pulmonary features and comorbidities have been studied and are considered essential components of comprehensive disease management, including lifestyle interventions. Despite these advances, predicting and/or modifying the course of the disease remains currently impossible, and selection of patients with a beneficial response to specific interventions is unsatisfactory. Consequently, non-response to pharmacologic and non-pharmacologic treatments is common, and many patients have refractory symptoms. Thus, there is an ongoing urgency for a more targeted a...Continue Reading

Citations

Oct 31, 2019·Thorax·Daisy J A Janssen, Miriam J Johnson
Feb 27, 2020·Expert Review of Pharmacoeconomics & Outcomes Research·Michael HindelangReiner Leidl
Mar 14, 2020·Expert Review of Respiratory Medicine·Evgeni MekovRosen Petkov
Feb 13, 2020·Pulmonary Therapy·Eric MlodzinskiLeo A Celi
Sep 30, 2020·Journal of Clinical Medicine·Kazuto MatsunagaTsunahiko Hirano
Mar 11, 2021·International Journal of Chronic Obstructive Pulmonary Disease·Kristijonas PuteikisElena Jurevičienė
Mar 20, 2021·Critical Reviews in Clinical Laboratory Sciences·Maryam Saberi-KarimianMajid Ghayour-Mobarhan
May 7, 2021·International Journal of Chronic Obstructive Pulmonary Disease·Kristian BratVladimir Koblizek
Dec 29, 2020·Semergen·A Hidalgo RequenaR Martos García
Oct 28, 2020·Journal of Medicinal Chemistry·Carlo BaggioMaurizio Pellecchia

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Methods Mentioned

BETA
pharmacotherapies
pharmacotherapy
single cell sequencing
flow cytometry

Software Mentioned

CDSS

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