Personalized Medicine in the Oncology Clinic: Implementation and Outcomes of the Johns Hopkins Molecular Tumor Board

JCO Precision Oncology
W Brian DaltonJosh Lauring

Abstract

Tumor genomic profiling for personalized oncology therapy is being widely applied in clinical practice even as it is being evaluated more formally in clinical trials. Given the complexities of genomic data and its application to clinical use, molecular tumor boards with diverse expertise can provide guidance to oncologists and patients seeking to implement personalized genetically targeted therapy in practice. A multidisciplinary molecular tumor board reviewed tumor molecular profiling reports from consecutive referrals at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins over a 3-year period. The tumor board weighed evidence for actionability of genomic alterations identified by molecular profiling and provided recommendations including US Food and Drug Administration-approved drug therapy, clinical trials of matched targeted therapy, off-label use of such therapy, and additional tumor or germline genetic testing. One hundred fifty-five patients were reviewed. Actionable genomic alterations were identified in 132 patients (85%). Off-label therapies were recommended in 37 patients (24%). Eleven patients were treated off-label, and 13 patients were enrolled onto clinical trials of matched targeted therapies. Median ...Continue Reading

References

Apr 24, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Julien MazièresOliver Gautschi
Mar 29, 2014·Cancer Discovery·Luc FribouletJeffrey A Engelman
May 7, 2014·The Oncologist·Maria SchwaederleRazelle Kurzrock
Jul 6, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Apostolia-Maria TsimberidouDonald Berry
Jul 16, 2014·Seminars in Oncology·Barbara A Conley, James H Doroshow
Oct 30, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ryohei KatayamaNaoya Fujita
Dec 6, 2014·Journal of the National Cancer Institute·Frederic J KayeRobert W Allan
Apr 12, 2015·Journal of the National Cancer Institute·Funda Meric-BernstamGordon B Mills
May 28, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Funda Meric-BernstamGordon B Mills
Aug 20, 2015·The New England Journal of Medicine·David M HymanJosé Baselga
Sep 1, 2015·International Journal of Cancer. Journal International Du Cancer·Jeffrey S RossPhilip J Stephens
Sep 16, 2015·Proceedings of the National Academy of Sciences of the United States of America·Monika A DavareBrian J Druker
Oct 28, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gabriel N HortobagyiJosé Baselga
Nov 11, 2015·Journal of the National Comprehensive Cancer Network : JNCCN·Razelle KurzrockF Marc Stewart
Nov 26, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J MazièresO Gautschi
May 7, 2016·Nature Medicine·Lillian L SiuEmile E Voest
Sep 30, 2016·The New England Journal of Medicine·Ian F Tannock, John A Hickman
Dec 14, 2016·Journal of the National Comprehensive Cancer Network : JNCCN·Justin LeeBen Ho Park

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Citations

Jan 9, 2019·Expert Review of Molecular Diagnostics·Andrew J McKenzieHoward Burris
Aug 7, 2019·Oncotarget·Mary K NeslineCarl Morrison
Apr 3, 2020·Cold Spring Harbor Molecular Case Studies·Patience ObasajuChristine A Pratilas
Dec 6, 2020·Archives of Gynecology and Obstetrics·Elena SultovaRachel Wuerstlein

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