Personalized Medicine: Review and Perspectives of Promising Baseline EEG Biomarkers in Major Depressive Disorder and Attention Deficit Hyperactivity Disorder

Neuropsychobiology
Sebastian OlbrichMartijn Arns

Abstract

Personalized medicine in psychiatry is in need of biomarkers that resemble central nervous system function at the level of neuronal activity. Electroencephalography (EEG) during sleep or resting-state conditions and event-related potentials (ERPs) have not only been used to discriminate patients from healthy subjects, but also for the prediction of treatment outcome in various psychiatric diseases, yielding information about tailored therapy approaches for an individual. This review focuses on baseline EEG markers for two psychiatric conditions, namely major depressive disorder and attention deficit hyperactivity disorder. It covers potential biomarkers from EEG sleep research and vigilance regulation, paroxysmal EEG patterns and epileptiform discharges, quantitative EEG features within the EEG main frequency bands, connectivity markers and ERP components that might help to identify favourable treatment outcome. Further, the various markers are discussed in the context of their potential clinical value and as research domain criteria, before giving an outline for future studies that are needed to pave the way to an electrophysiological biomarker-based personalized medicine.

Citations

Mar 28, 2017·Scientific Reports·Frank M SchmidtUlrich Hegerl
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Feb 17, 2018·Scientific Reports·Michel J A M van PuttenMartijn Arns
May 1, 2019·Journal of Child and Adolescent Psychopharmacology·Molly McVoyMartha Sajatovic
Feb 8, 2019·Frontiers in Psychiatry·Mark J Schiller
Jan 29, 2019·Frontiers in Human Neuroscience·Jennifer J Newson, Tara C Thiagarajan
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Nov 28, 2020·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Charlotte L RoelofsMartijn Arns
Jan 23, 2021·Neuroscience and Biobehavioral Reviews·Stephanie HomanPhilipp Homan
May 16, 2021·Biological Psychology·Mateo de BardeciSebastian Olbrich
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Aug 15, 2019·Stereotactic and Functional Neurosurgery·Karim MithaniNir Lipsman
Jan 16, 2022·Biological Psychology·Martijn ArnsSebastian Olbrich

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