Personalized Perioperative Multi-scale, Multi-physics Heart Simulation of Double Outlet Right Ventricle

Annals of Biomedical Engineering
Taro KariyaToshiaki Hisada

Abstract

For treatment of complex congenital heart disease, computer simulation using a three-dimensional heart model may help to improve outcomes by enabling detailed preoperative evaluations. However, no highly integrated model that accurately reproduces a patient's pathophysiology, which is required for this simulation has been reported. We modelled a case of complex congenital heart disease, double outlet right ventricle with ventricular septal defect and atrial septal defect. From preoperative computed tomography images, finite element meshes of the heart and torso were created, and cell model of cardiac electrophysiology and sarcomere dynamics was implemented. The parameter values of the heart model were adjusted to reproduce the patient's electrocardiogram and haemodynamics recorded preoperatively. Two options of in silico surgery were performed using this heart model, and the resulting changes in performance were examined. Preoperative and postoperative simulations showed good agreement with clinical records including haemodynamics and measured oxyhaemoglobin saturations. The use of a detailed sarcomere model also enabled comparison of energetic efficiency between the two surgical options. A novel in silico model of congenital h...Continue Reading

References

Feb 1, 1990·Pediatric Clinics of North America·J I Hoffman
Sep 1, 1996·Heart·D Sanchez-QuintanaS Y Ho
Aug 25, 2009·The Journal of Thoracic and Cardiovascular Surgery·Eugénie RiesenkampffTitus Kuehne
Nov 26, 2010·Journal of Biomechanics·Chiara CorsiniFrancesco Migliavacca
Oct 5, 2011·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·A BarettaUNKNOWN Modeling of Congenital Hearts Alliance (MOCHA) Investigators
Mar 27, 2012·Cellular and Molecular Bioengineering·Takumi WashioToshiaki Hisada
May 9, 2012·The Journal of Thoracic and Cardiovascular Surgery·Christopher M HaggertyAjit P Yoganathan
Jun 16, 2012·The Journal of Thoracic and Cardiovascular Surgery·Susumu KatayamaSeiryo Sugiura
Jan 30, 2013·Circulation·Edda BahlmannSimon Ray
Mar 7, 2013·Pacing and Clinical Electrophysiology : PACE·Jun-Ichi OkadaSeiryo Sugiura
Jul 25, 2013·Current Cardiology Reports·Michael A Quail, Andrew M Taylor
Oct 11, 2015·International Journal for Numerical Methods in Biomedical Engineering·Takumi WashioToshiaki Hisada
May 16, 2017·Journal of Molecular and Cellular Cardiology·Jun-Ichi OkadaSeiryo Sugiura
Aug 18, 2018·International Journal for Numerical Methods in Biomedical Engineering·Alfonso SantiagoMariano Vázquez

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Citations

Mar 20, 2021·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Hirotada MasudaYoshiki Sawa

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