Personalized Prognosis of Uveal Melanoma Based on Cytogenetic Profile in 1059 Patients over an 8-Year Period: The 2017 Harry S. Gradle Lecture

Ophthalmology
Carol L ShieldsArupa Ganguly

Abstract

To determine the personalized rate of uveal melanoma-related metastasis on the basis of individual tumor cytogenetic profile. Retrospective case series. A total of 1059 patients with uveal melanoma. Fine-needle aspiration biopsy (FNAB) for DNA amplification and whole genome array-based assay were performed for analysis of chromosomes 3, 6, and 8. Melanoma-related metastasis. The mean patient age was 57 years, and most were white (1026/1059, 97%). The melanoma involved the choroid (938/1059, 89%), ciliary body (85/1059, 8%), or iris (36/1059, 3%), with 19% being macular in location. The mean largest basal diameter was 11 mm (median, 12 mm; range, 3-24 mm), and mean thickness was 5 mm (median, 4 mm; range, 1-20 mm). On the basis of individual chromosomal mutations, risk for metastasis was increased for chromosome 3 partial monosomy (hazard ratio [HR], 2.84; P = 0.001), 3 complete monosomy (HR, 6.7, P < 0.001), 6q loss (HR, 3.1, P = 0.003), 8p loss (HR, 21.5, P < 0.001), and 8q gain (HR, 9.8, P < 0.001). Kaplan-Meier estimate for melanoma-related metastasis in 1, 3, 5, and 7 years for 3 partial monosomy was 1%, 5%, 14%, and 17%; for 3 complete monosomy was 3%, 19%, 28%, and 37%; for 6q loss was 8%, 23%, 49%, and 49%; for 8p loss w...Continue Reading

Citations

Jun 15, 2019·Singapore Medical Journal·Wendy WongLingam Gopal
Jul 10, 2019·Pigment Cell & Melanoma Research·Eric LondinIsidore Rigoutsos
Nov 13, 2018·Retina·Duncan E BerryUNKNOWN Ocular Oncology Study Consortium
Jul 11, 2018·Journal of Current Ophthalmology·Babak MasoomianCarol L Shields
Apr 2, 2019·Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society·Basil K WilliamsCarol L Shields
May 15, 2018·Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society·Carol L ShieldsArupa Ganguly
Apr 27, 2019·Translational Vision Science & Technology·Armin R AfsharBoris C Bastian
Jan 24, 2020·Retina·Duncan E BerryUNKNOWN Ocular Oncology Study Consortium
May 15, 2018·F1000Research·Amy C Schefler, Ryan S Kim
Jul 22, 2020·Eye·Roman DunavoelgyiJose S Pulido
Aug 2, 2019·Cancers·Luisa FrizzieroRaffaele Parrozzani
Apr 11, 2020·Nature Reviews. Disease Primers·Martine J JagerBertil E Damato
Oct 1, 2020·Cancers·Fabiana MalloneAntonietta Moramarco
Oct 24, 2020·International Ophthalmology Clinics·Basil K Williams, Maura Di Nicola
Feb 21, 2021·American Journal of Clinical Pathology·Minhua WangGuoping Cai
Jul 12, 2018·Retinal Cases & Brief Reports·Babak MasoomianJerry A Shields
Jun 18, 2021·Journal of Experimental & Clinical Cancer Research : CR·Prisca BustamanteJulia V Burnier
Jun 20, 2021·Indian Journal of Ophthalmology·Carol L ShieldsJerry A Shields
Aug 14, 2019·Retinal Cases & Brief Reports·Arman MashayekhiJerry A Shields
Jan 3, 2020·Retinal Cases & Brief Reports·Arman MashayekhiJerry A Shields

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