Personalizing and Optimizing Preventive Intervention Models via a Translational Neuroscience Framework

Prevention Science : the Official Journal of the Society for Prevention Research
Diana H Fishbein, Jacinda K Dariotis


A new generation of research, building upon developmental psychopathology (Luthar et al. 1997; Luthar et al. (Child Development, 71, 543-562, 2000)), provides evidence that individual differences in risk for behavioral health problems result from intrapersonal and environmental modulation of neurophysiologic and genetic substrates. This transdisciplinary model suggests that, in any given individual, the number of genetic variants implicated in high-risk behavior and the way in which they are assorted and ultimately suppressed or activated in the brain by experiential and contextual factors help to explain behavioral orientations. Implications are that behavioral health problems can be amplified or reduced based on characteristics of an individual and socio-contextual influences on those characteristics. This emerging research has extraordinary implications for the design of prevention programs that more precisely target the malleable mechanisms that underlie behavioral health problems and, hence, more effectively prevent behavioral problems and promote resilience. A detailed, theory-driven examination of all evidence-based interventions is called for to identify the active ingredients that specifically impact these underlying m...Continue Reading


Jul 20, 2000·The Journal of School Health·M J Elias, R P Weissberg
Oct 3, 2000·Development and Psychopathology·M I Posne, M K Rothbart
Nov 9, 2000·Journal of the American Academy of Child and Adolescent Psychiatry·P A FisherJ B Reid
Dec 28, 2000·Addictive Behaviors·D R Offord
Feb 13, 2001·Brain and Cognition·K C KoenenL Schlesinger
Feb 24, 2001·Development and Psychopathology·S S Lutha, D Cicchetti
Jul 21, 2001·Annals of the New York Academy of Sciences·K E McKay, J M Halperin
Aug 28, 2001·Prevention Science : the Official Journal of the Society for Prevention Research·D Fishbein
Mar 15, 2003·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Peter Anderson
Jun 10, 2003·Journal of Personality and Social Psychology·Jeff JoiremanAlan Strathman
Jul 29, 2003·Psychosomatic Medicine·Richard J DavidsonJohn F Sheridan
Apr 2, 2004·Child Development·Martha Ann Bell, Christy D Wolfe
Jan 15, 2005·Clinical Child and Family Psychology Review·Steven W Evans, Mark D Weist
Sep 13, 2005·Drug and Alcohol Dependence·Diana H FishbeinBetty Yung
Sep 22, 2005·The American Psychologist·John R WeiszBarry S Anton
Mar 30, 2006·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·Paula M C MommersteegLorenz J P van Doornen
Mar 31, 2006·Prevention Science : the Official Journal of the Society for Prevention Research·Nathaniel R RiggsMary Ann Pentz
Mar 10, 2007·Annals of the New York Academy of Sciences·Mark T Greenberg
Dec 14, 2007·Substance Abuse : Official Publication of the Association for Medical Education and Research in Substance Abuse·Thomas F BaborJeremy Bray
Jul 9, 2008·Development and Psychopathology·Karen L BiermanCelene E Domitrovich
Feb 23, 2010·Perspectives in Biology and Medicine·Ben A Williams
Apr 28, 2010·Proceedings of the National Academy of Sciences of the United States of America·Koji JimuraTodd S Braver
Apr 28, 2010·Prevention Science : the Official Journal of the Society for Prevention Research·George W HoweGene H Brody
May 5, 2010·Journal of Abnormal Child Psychology·Tamar MendelsonPhilip J Leaf
Dec 7, 2010·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Linda M CollinsMichael C Fiore
Dec 28, 2011·Pediatrics·Jack P ShonkoffUNKNOWN Section on Developmental and Behavioral Pediatrics
Feb 22, 2012·Consciousness and Cognition·K K F RochaR H Silva
May 31, 2012·American Journal of Community Psychology·Duncan C MeyersAbraham Wandersman
Aug 3, 2012·Frontiers in Integrative Neuroscience·Brett E FroeligerF Joseph McClernon
Nov 6, 2012·Neuroscience·L Eiland, R D Romeo
Jan 22, 2013·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Linda Patia Spear
Feb 5, 2013·Health Promotion International·Sandro CorrieriSteffi G Riedel-Heller

❮ Previous
Next ❯


Jan 19, 2018·Prevention Science : the Official Journal of the Society for Prevention Research·Mary Bruce Webb
Jan 24, 2019·Prevention Science : the Official Journal of the Society for Prevention Research·Ty A Ridenour
Oct 27, 2018·Prevention Science : the Official Journal of the Society for Prevention Research·Gerald J August, Abigail Gewirtz
Sep 5, 2019·Prevention Science : the Official Journal of the Society for Prevention Research·Michael ThierHuna Yim-Dockery
Sep 5, 2020·Prevention Science : the Official Journal of the Society for Prevention Research·Zili Sloboda, Susan B David

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Landau-Kleffner Syndrome

Landau Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, or aphasia with convulsive disorder, is a rare childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram. Discover the latest research on LKS here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.