Personalizing and Optimizing Preventive Intervention Models via a Translational Neuroscience Framework

Prevention Science : the Official Journal of the Society for Prevention Research
Diana H Fishbein, Jacinda K Dariotis

Abstract

A new generation of research, building upon developmental psychopathology (Luthar et al. 1997; Luthar et al. (Child Development, 71, 543-562, 2000)), provides evidence that individual differences in risk for behavioral health problems result from intrapersonal and environmental modulation of neurophysiologic and genetic substrates. This transdisciplinary model suggests that, in any given individual, the number of genetic variants implicated in high-risk behavior and the way in which they are assorted and ultimately suppressed or activated in the brain by experiential and contextual factors help to explain behavioral orientations. Implications are that behavioral health problems can be amplified or reduced based on characteristics of an individual and socio-contextual influences on those characteristics. This emerging research has extraordinary implications for the design of prevention programs that more precisely target the malleable mechanisms that underlie behavioral health problems and, hence, more effectively prevent behavioral problems and promote resilience. A detailed, theory-driven examination of all evidence-based interventions is called for to identify the active ingredients that specifically impact these underlying m...Continue Reading

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Citations

Jan 19, 2018·Prevention Science : the Official Journal of the Society for Prevention Research·Mary Bruce Webb
Jan 24, 2019·Prevention Science : the Official Journal of the Society for Prevention Research·Ty A Ridenour
Oct 27, 2018·Prevention Science : the Official Journal of the Society for Prevention Research·Gerald J August, Abigail Gewirtz
Sep 5, 2019·Prevention Science : the Official Journal of the Society for Prevention Research·Michael ThierHuna Yim-Dockery
Sep 5, 2020·Prevention Science : the Official Journal of the Society for Prevention Research·Zili Sloboda, Susan B David

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