Personalizing surgical margins in retroperitoneal sarcomas

Expert Review of Anticancer Therapy
Dario CallegaroAlessandro Gronchi

Abstract

Retroperitoneal sarcomas are a group of diseases that behave differently from one another. Well-differentiated liposarcomas have an indolent biology but show a tendency to recur locally even years after primary resection. Dedifferentiated liposarcomas are characterized by a very high local recurrence risk, while the metastatic risk mainly depends on the histological characteristics of the dedifferentiated component. In leiomyosarcomas, hematogenous spread informs prognosis while local recurrences are far less common. Surgery is the cornerstone of treatment of all retroperitoneal sarcoma subtypes and its quality is the only treatment-related factor able to improve the oncological outcome. A frontline extended surgical approach is all the more critical in subtypes in which local control directly impacts prognosis.

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Citations

Sep 24, 2015·The British Journal of Surgery·H G SmithD C Strauss
Apr 5, 2016·Expert Review of Anticancer Therapy·Maristella SaponaraAlessandro Gronchi
May 26, 2016·Der Urologe. Ausg. A·O Schmalz
Jan 21, 2017·F1000Research·Nadar A NassifBurton Eisenberg
Jun 5, 2019·Expert Review of Anticancer Therapy·Brittany DingleyAlessandro Gronchi
Dec 9, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Joseph G CromptonFritz C Eilber
May 29, 2020·Current Treatment Options in Oncology·Gaya SpolveratoAlessandro Gronchi
Jul 18, 2019·Annals of Surgical Oncology·Eran NizriAlessandro Gronchi
Oct 13, 2018·World Journal of Surgical Oncology·Michael J NathensonEdward Sausville
May 12, 2017·Cancer·Dario CallegaroAlessandro Gronchi
Apr 22, 2021·Current Opinion in Oncology·Dario CallegaroAlessandro Gronchi

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