Personalizing the diuretic treatment of hypertension: the need for more clinical and research attention

Current Hypertension Reports
Samuel J Mann, Michael E Ernst

Abstract

Neither randomized controlled trials nor efforts to identify genetic markers have been helpful with regard to the goal of individualizing diuretic therapy in the treatment of hypertension, a goal that receives little clinical or research attention. This review will examine, and bring attention to, the considerable yet overlooked information relevant to individualizing diuretic therapy. It will bring attention to clinical, biochemical, and pharmacological clues that can be helpful in identifying who is likely to respond to a diuretic, who needs a stronger diuretic regimen, which diuretic to prescribe, and how to minimize adverse effects. New directions for clinical research aimed at individualizing use in hypertension will be explored. Research and clinical attention to the goal of individualizing diuretic treatment in hypertension need to be renewed, to help us achieve greater hypertension control with fewer adverse effects and lower costs.

References

Jul 1, 1977·Clinical Pharmacology and Therapeutics·C S BrooksT A Kotchen
Apr 1, 1977·Journal of Clinical Pharmacology·R R Paton, R E Kane
Aug 20, 1992·The New England Journal of Medicine·J F Setaro, H R Black
Jan 1, 1991·Drugs·D C Brater
Feb 1, 1990·The New England Journal of Medicine·A Z LaCroixA M Ostfeld
Oct 1, 1987·The American Journal of Cardiology·X JeunemaitreJ Menard
Oct 1, 1973·The American Journal of Physiology·P C Fernandez, J B Puschett
Mar 1, 1984·The American Journal of Cardiology·A P Niarchos, J H Laragh
Nov 1, 1983·The Journal of Clinical Endocrinology and Metabolism·D LepplaC Y Pak
Feb 1, 1983·Age and Ageing·S G Sunderam, G D Mankikar
Aug 11, 1983·The New England Journal of Medicine·R D WasnichJ M Vogel
Jun 1, 1982·The American Journal of Medicine·G L WollamH P Dustan
Jul 1, 1981·Archives of Internal Medicine·C V RamN M Kaplan
Jan 1, 1993·Cardiovascular Drugs and Therapy·P Baumgart
Aug 6, 1998·The New England Journal of Medicine·D C Brater
May 29, 2000·The New England Journal of Medicine·H J Adrogué, N E Madias
May 23, 2002·Hypertension·Sandra J TalerJo Ellen Augustine
Jul 10, 2002·Hypertension·Emma H BakerGraham A MacGregor
Aug 9, 2002·European Journal of Heart Failure·Juan CosínUNKNOWN TORIC investigators
Dec 20, 2002·JAMA : the Journal of the American Medical Association·UNKNOWN ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. The Antihypertensive and Lipid-Lowering Treatm
Oct 24, 2003·American Journal of Hypertension·Mari Konishi NishizakaDavid A Calhoun
Oct 24, 2003·The New England Journal of Medicine·Brian L StromDan Pettitt
Dec 6, 2003·Hypertension·Aram V ChobanianUNKNOWN National High Blood Pressure Education Program Coordinating Committee
Feb 22, 2005·The Journal of Clinical Hypertension·Ari Mosenkis, Raymond R Townsend
Aug 10, 2005·The Journal of Clinical Hypertension·Nitin KhoslaGeorge L Bakris
Apr 2, 2008·The New England Journal of Medicine·UNKNOWN ONTARGET InvestigatorsCraig Anderson
Apr 12, 2008·Clinical Cardiology·Allan StruthersGordon H Williams
Jun 14, 2008·The Journal of Clinical Hypertension·Samuel J Mann
Nov 5, 2008·Hypertension·Tariq ShafiRulan S Parekh
Dec 5, 2008·The New England Journal of Medicine·Kenneth JamersonUNKNOWN ACCOMPLISH Trial Investigators

❮ Previous
Next ❯

Citations

Mar 10, 2016·Current Hypertension Reports·Line Malha, Samuel J Mann
Jun 23, 2016·Journal of the American Heart Association·Pauliina KangasIlkka Pörsti

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

© 2021 Meta ULC. All rights reserved