Perspective: Adhesion Mediated Signal Transduction in Bacterial Pathogens

Pathogens
Sudha MoorthyEric A Klein

Abstract

During the infection process, pathogenic bacteria undergo large-scale transcriptional changes to promote virulence and increase intrahost survival. While much of this reprogramming occurs in response to changes in chemical environment, such as nutrient availability and pH, there is increasing evidence that adhesion to host-tissue can also trigger signal transduction pathways resulting in differential gene expression. Determining the molecular mechanisms of adhesion-mediated signaling requires disentangling the contributions of chemical and mechanical stimuli. Here we highlight recent work demonstrating that surface attachment drives a transcriptional response in bacterial pathogens, including uropathogenic Escherichia coli (E. coli), and discuss the complexity of experimental design when dissecting the specific role of adhesion-mediated signaling during infection.

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Citations

Sep 14, 2018·Acta Veterinaria Scandinavica·Mengcheng LiuWenlong Zhang
Mar 12, 2020·Nature Communications·Naama Lahav-MankovskiDavid Margulies
Dec 4, 2016·Biochemical Society Transactions·Daniel Henry Stones, Anne Marie Krachler
Aug 1, 2016·FEMS Microbiology Reviews·Damián Lobato-MárquezFrancisco García-Del Portillo
Dec 2, 2017·ACS Applied Materials & Interfaces·Paulius MikulskisDavid A Winkler
Apr 20, 2019·Kidney Diseases·Ankur MittalDibyajyoti Banerjee

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Methods Mentioned

BETA
PCR
dissection

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