Perspective: Dynamics of receptor tyrosine kinase signaling complexes.

FEBS Letters
Bruce J Mayer

Abstract

Textbook descriptions of signal transduction complexes provide a static snapshot view of highly dynamic events. Despite enormous strides in identifying the key components of signaling complexes and the underlying mechanisms of signal transduction, our understanding of the dynamic behavior of these complexes has lagged behind. Using the example of receptor tyrosine kinases, this perspective takes a fresh look at the dynamics of the system and their potential impact on signal processing.

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Citations

Nov 9, 2012·Cell Communication and Signaling : CCS·Tomonori KanekoShawn Sc Li
Dec 17, 2014·BioMed Research International·Narcisa Martinez-QuilesPhilip R Hardwidge
Jul 3, 2013·Expert Opinion on Investigational Drugs·Matteo MorottiSimone Ferrero
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Jun 17, 2020·The Journal of Biological Chemistry·Rachel Jaber ChehayebTitus J Boggon
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Nov 2, 2018·Nature Communications·Tomonori KanekoShawn S-C Li
Mar 7, 2021·International Journal of Molecular Sciences·Manali TilakNina Jones

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Cell Signaling by Tyrosine Kinases

Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. RTKs have been shown not only to be key regulators of normal cellular processes but also to have a critical role in the development and progression of many types of cancer. Discover the latest research on cell signaling and RTK here.

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