Perspective review on solid-organ transplant: needs in point-of-care optical biomarkers

Journal of Biomedical Optics
Daqing PiaoErin M Rubin

Abstract

Solid-organ transplant is one of the most complex areas of modern medicine involving surgery. There are challenging opportunities in solid-organ transplant, specifically regarding the deficiencies in pathology workflow or gaps in pathology support, which may await alleviations or even de novo solutions, by means of point-of-care, or point-of-procedure optical biomarkers. Focusing the discussions of pathology workflow on donor liver assessment, we analyze the undermet need for intraoperative, real-time, and nondestructive assessment of the donor injuries (such as fibrosis, steatosis, and necrosis) that are the most significant predictors of post-transplant viability. We also identify an unmet need for real-time and nondestructive characterization of ischemia or irreversible injuries to the donor liver, earlier than appearing on morphological histology examined with light microscopy. Point-of-procedure laparoscopic optical biomarkers of liver injuries and tissue ischemia may also facilitate post-transplant management that is currently difficult for or devoid of pathological consultation due to lack of tools. The potential and pitfalls of point-of-procedure optical biomarkers for liver assessment are exemplified in breadth for ste...Continue Reading

References

Oct 1, 1972·Journal of Pediatric Surgery·J R LillyJ G Randolph
Feb 1, 1968·Proceedings of the Society for Experimental Biology and Medicine·E RubinJ H Jacobson
Jun 1, 1995·Journal of Hepatology·K IshakR N MacSween
Jan 17, 1996·Annals of the New York Academy of Sciences·C HockA Villringer
Jul 27, 1997·Transplantation·T M FishbeinP A Sheiner
Mar 6, 1999·Annals of Internal Medicine·P Kefalides
Oct 3, 2000·Surgery·A M D'alessandroM Kalayoglu
Mar 1, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Desley A H Neil, Stefan G Hubscher
Jul 29, 2003·Transplantation·Yuji SoejimaKeizo Sugimachi
Nov 10, 2005·The Journal of Clinical Endocrinology and Metabolism·Anelia HorvathConstantine A Stratakis
Mar 17, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S FengR M Merion
Dec 25, 2007·American Journal of Surgery·Martin K AngeleFlorian Loehe
Mar 17, 2010·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Ajay K SinghGiles W Boland
Mar 23, 2010·The Journal of Urology·Maristela L OnozatoYu Chen
Aug 21, 2010·Transplant International : Official Journal of the European Society for Organ Transplantation·Desley A H Neil, Stefan G Hübscher
Nov 5, 2010·Physics in Medicine and Biology·B L McLaughlinP A Robertson
Nov 9, 2010·Journal of Biomedical Optics·Yuting HeHanry Yu
Dec 15, 2010·Journal of Hepatology·Lucas McCormackPierre-Alain Clavien
Jan 18, 2013·World Journal of Gastroenterology : WJG·Shira Zelber-SagiErwin Santo
Feb 2, 2013·Archives of Pathology & Laboratory Medicine·Claire MelinManjula Balasubramanian
Mar 6, 2013·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Richard S YoungK Rajendra Prasad
Sep 14, 2013·Hepatitis Monthly·Bita GeramizadehSeyed Ali Malek Hosseini
Nov 29, 2013·Surgical Infections·Laura H RosenbergerRobert G Sawyer
Jun 6, 2014·Environmental Science. Processes & Impacts·Jon AgustssonLuca Rossi
Dec 3, 2014·Journal of Molecular and Cellular Cardiology·Elizabeth Murphy
Jan 6, 2015·Transplant International : Official Journal of the European Society for Organ Transplantation·Daniel J EversTheo J M Ruers
Jan 30, 2015·JAMA Surgery·Abbas RanaRainer W G Gruessner
Sep 4, 2015·Gastroenterology·John M CarethersBruce E Sands

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