Perspective: What Makes It So Difficult to Mitigate Worldwide Anemia Prevalence?

Advances in Nutrition
Klaus Schümann, Noel W Solomons

Abstract

Anemia can be related to decreased production or increased loss of erythrocytes, or both, leading to many underlying and often overlapping causes. A largely cereal-based diet with plenty of phytates, polyphenols, and other ligands that inhibit intestinal iron absorption predominated in preindustrial Europe and predominates in present-day developing countries alike. In both situations, we find poor hygienic conditions, which frequently lead to anemia of inflammation. The large number of possible causes and their interaction shows why it is so difficult to mitigate anemia prevalence. Diagnostic biomarkers are required to differentiate the different types of anemia and to treat them appropriately. Some of them are well established in adults [e.g., concentrations of serum ferritin, soluble transferrin receptor (sTfR), and serum iron or the ratio of sTfR to log ferritin]. Others, such as serum hepcidin, hold considerable promise, although they are not yet widely used. A particular issue is to establish reference values for biomarkers in infants and children at different ages. The fact that resource-rich postindustrial societies have a very low prevalence of iron-deficiency anemia offers hope that common types of anemia can be elimin...Continue Reading

Associated Clinical Trials

Apr 17, 2018·Andrew Jones

Citations

Sep 10, 2020·International Journal of Environmental Research and Public Health·So Young KimHyo Geun Choi
Oct 24, 2020·Expert Review of Anti-infective Therapy·Lara Valente de SouzaGünter Weiss
Jun 10, 2021·Current Developments in Nutrition·Monica M PasqualinoKeith P West

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Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

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