Perspectives and limitations for nucleo(t)side analogs in future HBV therapies

Current Opinion in Virology
Massimo LevreroFabien Zoulim

Abstract

The latest generation of nucleo(t)side analogs (NAs) provide robust virus suppression with high barrier to resistance. Long term NAs treatment is associated with a partial restoration in HBV-specific T-cell functions, regression of fibrosis, no disease progression and a reduction of HCC risk but rarely lead to cure and life-long treatments is often required. New insights into the hepatitis B viral life cycle and the host immune response have expanded the potential targets for drug therapies with interesting antiviral candidates and novel immunotherapeutic approaches in early stage development. Here we review the mode of action of current drugs (NAs and PEG IFN) and new classes of anti-HBV compounds, focusing on the possible role of nucleo(t)side analogs in future combination therapies.

Citations

Apr 19, 2019·PloS One·Pierre GantnerUNKNOWN Dat’AIDS Study Group
Dec 13, 2019·Journal of Viral Hepatitis·Robert J FontanaMaria Beumont
May 16, 2019·Journal of Viral Hepatitis·Qin NingFu-Sheng Wang
Sep 25, 2019·Nature Reviews. Gastroenterology & Hepatology·Mala K Maini, Alice R Burton
Apr 9, 2020·Cells·Natascha RoehlenThomas F Baumert
Jun 15, 2019·International Journal of Molecular Sciences·Carolina BoniPaola Fisicaro
Sep 25, 2019·Antiviral Research·Enzo TramontanoLuis Menéndez-Arias
Mar 27, 2021·Journal of Virological Methods·Qilan LiJohn E Tavis
Mar 28, 2021·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Tao LiLei Wang
May 1, 2021·Vaccines·Sheikh Mohammad Fazle AkbarYoichi Hiasa
Oct 26, 2021·Antimicrobial Agents and Chemotherapy·Daniel P BradleyJohn E Tavis

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