Perspectives for angiotensin profiling with liquid chromatography/mass spectrometry to evaluate ACE/ACE2 balance in endothelial dysfunction and vascular pathologies

Pharmacological Reports : PR
Mariola OlkowiczRyszard T Smolenski

Abstract

Vascular injury, characterized by endothelial dysfunction, inflammation, structural remodeling, thrombosis and calcification leads to cardiovascular diseases. Angiotensin (Ang) II (1-8) - synthesized mainly by angiotensin converting enzyme (ACE) is the best characterized mediator of the renin-angiotensin system (RAS). This peptide initially identified by its vasoactive properties was found to play a major role in vascular response to insult. However, recent discovery of angiotensin converting enzyme 2 (ACE2) that produces vasoprotective Ang-(1-7) peptide highlighted complexity of the system and suggested that balance between ACE/Ang II and ACE2/Ang-(1-7) is fundamental in maintaining vascular homeostasis and its disorders are associated with cardiovascular pathology. There is therefore a need to develop methods for comprehensive analysis of biologically active Ang peptides and their metabolites of ACE/Ang II and ACE2/Ang-(1-7) axes. Liquid chromatography/mass spectrometry (LC/MS) is an analytical technique that offers potential for specific, simultaneous analysis of Ang peptides. With sensitivity added by application of preconcentration nanochromatography reaching picomolar concentrations, practically all Ang peptides identifie...Continue Reading

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Citations

Sep 1, 2015·Pharmacological Reports : PR·Stefan Chlopicki
Jul 28, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Tawar QaradakhiAnthony Zulli
Sep 20, 2020·International Journal of Molecular Sciences·Arun Samidurai, Anindita Das
Sep 19, 2020·PloS One·Davide GolinelliMaria Pia Fantini
Dec 14, 2018·Experimental and Therapeutic Medicine·Haiming DangHongjia Zhang
Sep 9, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Richard A Stein, Lauren M Young

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