Perspectives for clinical use of engineered human host defense antimicrobial peptides

FEMS Microbiology Reviews
María Eugenia Pachón-IbáñezJavier Sánchez-Céspedes

Abstract

Infectious diseases caused by bacteria, viruses or fungi are among the leading causes of death worldwide. The emergence of drug-resistance mechanisms, especially among bacteria, threatens the efficacy of all current antimicrobial agents, some of them already ineffective. As a result, there is an urgent need for new antimicrobial drugs. Host defense antimicrobial peptides (HDPs) are natural occurring and well-conserved peptides of innate immunity, broadly active against Gram-negative and Gram-positive bacteria, viruses and fungi. They also are able to exert immunomodulatory and adjuvant functions by acting as chemotactic for immune cells, and inducing cytokines and chemokines secretion. Moreover, they show low propensity to elicit microbial adaptation, probably because of their non-specific mechanism of action, and are able to neutralize exotoxins and endotoxins. HDPs have the potential to be a great source of novel antimicrobial agents. The goal of this review is to provide an overview of the advances made in the development of human defensins as well as the cathelicidin LL-37 and their derivatives as antimicrobial agents against bacteria, viruses and fungi for clinical use.

References

Dec 1, 1989·The Journal of Clinical Investigation·M C TerritoR Lehrer
Oct 1, 1985·The Journal of Clinical Investigation·T GanzR I Lehrer
Dec 1, 1986·Journal of Virology·K A DaherR I Lehrer
May 1, 1993·Medicinal Research Reviews·R A Wiley, D H Rich
Mar 6, 1998·Trends in Biotechnology·R E Hancock, R Lehrer
Sep 16, 1998·Antimicrobial Agents and Chemotherapy·J TurnerR I Lehrer
Jul 15, 1999·The International Journal of Biochemistry & Cell Biology·J M Schröder, J Harder
Feb 16, 2000·Journal of Peptide Science : an Official Publication of the European Peptide Society·N F DawsonJ D Wade
Nov 18, 2000·Antimicrobial Agents and Chemotherapy·M EdgertonJ A Bruenn
Feb 24, 2001·Cellular and Molecular Life Sciences : CMLS·J M Schröder
Apr 20, 2001·Seminars in Respiratory Infections·T Ganz
Jun 19, 2001·Biological Chemistry·W van 't HofA V Amerongen
Jan 25, 2002·Nature·Michael Zasloff
Feb 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Alexander M ColeRobert I Lehrer
Feb 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Brian C SchuttePaul B McCray
Apr 23, 2002·Current Medicinal Chemistry·Celine Adessi, Claudio Soto
Dec 21, 2002·Immunological Reviews·ToddE ScheetzPaul B McCray
Apr 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wei WangRobert I Lehrer
Aug 26, 2003·Antimicrobial Agents and Chemotherapy·David M HooverJacek Lubkowski
Oct 9, 2003·Applied and Environmental Microbiology·Mônica C Triches DamasoRodolpho M Albano
Oct 23, 2003·AIDS·Miguel E Quiñones-MateuAaron Weinberg
Oct 31, 2003·AIDS Research and Human Retroviruses·Carsten MünkAlexander M Cole
Mar 9, 2004·Journal of Clinical Microbiology·Sophie JolyJanet M Guthmiller
Aug 20, 2004·The Journal of Peptide Research : Official Journal of the American Peptide Society·Z WuW Lu
Dec 1, 2004·Journal of Leukocyte Biology·Dawn M E BowdishRobert E W Hancock
Dec 8, 2004·Journal of Leukocyte Biology·Hans-Georg SahlAlessandro Tossi
Dec 14, 2004·AIDS Research and Human Retroviruses·Sherry M OwenRobert I Lehrer
Dec 24, 2004·Antimicrobial Agents and Chemotherapy·Bryan EricksenRobert I Lehrer
Dec 29, 2004·FEBS Letters·Zhibin WuWuyuan Lu
Apr 12, 2005·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Josef Johann SchneiderHans Christian Korting
Apr 16, 2005·Current Opinion in Biotechnology·Eva StogerPaul Christou
May 24, 2005·Nature Immunology·Michael E Selsted, Andre J Ouellette
Jun 29, 2005·The Journal of Investigative Dermatology·Belén López-GarcíaRichard L Gallo
Jul 16, 2005·Current Eye Research·Y Jerold GordonAlison M McDermott
Jul 23, 2005·Scandinavian Journal of Gastroenterology·Karlheinz KiehneKarl-Heinz Herzig
Aug 17, 2005·Protein and Peptide Letters·Ingrid Cipáková, Eva Hostinová
Sep 13, 2005·Nature Immunology·Eugenia LeikinaLeonid V Chernomordik

❮ Previous
Next ❯

Citations

May 10, 2017·FEMS Microbiology Reviews·Ehud BaninOscar P Kuipers
Oct 16, 2018·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Anna Herman, Andrzej P Herman
May 11, 2019·Soft Matter·Sarah R DennisonDavid A Phoenix
Jul 18, 2019·Fundamental & Clinical Pharmacology·Albert BolatchievElena Kunitsina
Jan 2, 2020·International Journal of Molecular Sciences·Krištof Bozovičar, Tomaž Bratkovič
Apr 28, 2020·Current Topics in Medicinal Chemistry·Rosa GaglioneAngela Arciello
Oct 4, 2020·Journal of Computer-aided Molecular Design·Hossein AghazadehKamran Pooshang Bagheri
Aug 15, 2019·Scientific Data·Xinyue KangHeng Zheng
Aug 4, 2019·Viruses·Aslaa AhmedAarthi Narayanan
Feb 29, 2020·Nature Reviews. Drug Discovery·Neeloffer MookherjeeDonald J Davidson
Aug 7, 2019·Current Medicinal Chemistry·David C Brice, Gill Diamond
Feb 11, 2020·Frontiers in Microbiology·Marlon H CardosoOctávio L Franco
Apr 19, 2018·Animal Frontiers : the Review Magazine of Animal Agriculture·Ronald R Marquardt, Suzhen Li
Dec 19, 2019·Frontiers in Pharmacology·Elizângela de BarrosElizabete S Cândido
Jun 27, 2020·Plastic and Reconstructive Surgery·Michael R DeLongPaul S Cederna
Apr 9, 2020·World Journal of Stem Cells·Yan-Li GaoPeng-Yu Chang
Sep 14, 2020·Stem Cell Reviews and Reports·Yogesh Kumar VermaGurudutta U Gangenahalli
Jun 23, 2020·Journal of Peptide Science : an Official Publication of the European Peptide Society·Athanasios TzitzilisEugenia Panou-Pomonis
Jan 21, 2021·Pharmaceutics·Annarita FalangaStefania Galdiero
Mar 31, 2019·Biochimica Et Biophysica Acta. Biomembranes·Isabel C M FensterseiferOctavio L Franco
Mar 21, 2021·Drug Discovery Today·Maurício G C SousaOctávio L Franco
May 3, 2021·Microbial Pathogenesis·Subhash Singh SolankiSyed Azmal Ali
Jun 3, 2021·International Journal of Molecular Sciences·Ming-Yieh PengYou-Chen Chao
Jul 3, 2021·Biomolecules·Marija PetkovicHåvard Jenssen
Jul 9, 2021·Frontiers in Molecular Biosciences·Santosh K Ghosh, Aaron Weinberg
Jul 2, 2021·Frontiers in Cellular and Infection Microbiology·Antonio MorettaPatrizia Falabella
May 26, 2021·Antimicrobial Agents and Chemotherapy·Vanessa DuncanDeborah O'Neil

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Related Papers

Cellular and Molecular Life Sciences : CMLS
Amy T Y YeungRobert E W Hancock
Archives of Otolaryngology--head & Neck Surgery
Jeong-Su WooHeung-Man Lee
Central-European Journal of Immunology
Justyna AgierEwa Brzezińska-Błaszczyk
© 2022 Meta ULC. All rights reserved