Perspectives in adjuvant therapy of gastric cancer

Oncology
Ferdinando De VitaMichele Orditura

Abstract

Although the incidence of gastric cancer has been declining in Western countries, it is still a major health problem and a leading cause of cancer mortality. Surgery is the mainstay of treatment for gastric adenocarcinoma. However, even among patients undergoing gastrectomy with curative intent, 5-year survival rates are disappointing due to locoregional relapse and distant metastases. This emphasizes the importance of multidisciplinary management of patients with gastric cancer. In contrast to the preoperative approach, several phase III trials have been carried out in the adjuvant setting, but postoperative chemotherapy has not proven to be superior to surgery alone. Therefore, at present the routine use of adjuvant therapy should be regarded as an investigational approach. Improved clinical trial designs with standardized surgical techniques and the incorporation of newer active drugs are needed.

Citations

Feb 18, 2011·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Amy T Y ChangAnne W M Lee
Mar 11, 2011·World Journal of Gastroenterology : WJG·Jun-Duo HuJin-Lian Chen
Feb 4, 2014·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Elodie HerbreteauAnne-Marie Bouvier
Nov 28, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jie WuCheng Dong
Aug 22, 2012·The Journal of International Medical Research·Y Y WangJ-H Wang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Related Papers

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Lionel LimTrevor Leong
Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
Leizhen ZhengKeping Xie
Surgical Oncology Clinics of North America
Sara M Johnson, B Mark Evers
© 2021 Meta ULC. All rights reserved