Perspectives of fixed daily dose of sofosbuvir and ledipasvir for the treatment of chronic hepatitis C

Expert Opinion on Pharmacotherapy
Annarosa Floreani

Abstract

The fixed dose combination of sofosbuvir and ledipasvir (SOF/LDV) has marked a new era for patients with chronic HCV because it is the first drug to be approved by the FDA that does not include peginterferon or ribavirin. The results of three clinical studies show that SOF/LDV has sustained virologic response of approximately 96% when given as once a day pill for 3 months to both treatment naive and treatment-experienced HCV-1 patients with the exception of prior null responder patients with cirrhosis. Moreover, emerging data in special populations (patients with decompensated cirrhosis, with post-transplant recurrence, with prior SOF-based therapy failure, and with HIV co-infection) show a good tolerance and high sustained virological profile. Many other emerging therapies are now available. Actually, the recommendations of the international guidelines are applicable only for selected patients followed-up by dedicated specialists, including hepatologists and infectologists, and are specifically individualized for patients with advanced fibrosis. We will expect that the landscape for management of HCV will include direct-acting antivirals for treatment of patients with different genotypes and low-grade fibrosis in order to inte...Continue Reading

References

Feb 7, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·David L WylesMark S Sulkowski
Mar 29, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Freimut SchliessSebastian Zellmer
Apr 12, 2014·The New England Journal of Medicine·Kris V KowdleyUNKNOWN ION-3 Investigators
Apr 12, 2014·The New England Journal of Medicine·Jordan J FeldBarry Bernstein
Apr 15, 2014·The New England Journal of Medicine·Nezam AfdhalUNKNOWN ION-2 Investigators
Apr 15, 2014·The New England Journal of Medicine·Nezam AfdhalUNKNOWN ION-1 Investigators
May 6, 2014·The New England Journal of Medicine·Peter FerenciUNKNOWN PEARL-IV Study
Feb 14, 2015·Expert Opinion on Pharmacotherapy·Radhika Kumari, Mindie H Nguyen

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