Perspectives on Cannabis-Based Therapy of Multiple Sclerosis: A Mini-Review

Frontiers in Cellular Neuroscience
Miriam MechaCarmen Guaza

Abstract

The consistency, efficacy, and safety of cannabis-based medicines have been demonstrated in humans, leading to the approval of the first cannabis-based therapy to alleviate spasticity and pain associated with multiple sclerosis (MS). Indeed, the evidence supporting the therapeutic potential of cannabinoids for the management of pathological events related to this disease is ever increasing. Different mechanisms of action have been proposed for cannabis-based treatments in mouse models of demyelination, such as Experimental Autoimmune Encephalomyelitis (EAE) and Theiler's Murine Encephalomyelitis Virus-Induced Demyelinating Disease (TMEV-IDD). Cells in the immune and nervous system express the machinery to synthesize and degrade endocannabinoids, as well as their CB1 and CB2 receptors, each mediating different intracellular pathways upon activation. Hence, the effects of cannabinoids on cells of the immune system, on the blood-brain barrier (BBB), microglia, astrocytes, oligodendrocytes and neurons, potentially open the way for a plethora of therapeutic actions on different targets that could aid the management of MS. As such, cannabinoids could have an important impact on the outcome of MS in terms of the resolution of inflamma...Continue Reading

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Citations

Jun 9, 2021·Molecular Brain·Hajar Miranzadeh MahabadiChangiz Taghibiglou
Jun 23, 2021·Neuropharmacology·Ana CoveloGiovanni Marsicano
Jun 26, 2021·Journal of Ethnopharmacology·Manica BalantTeresa Garnatje
Aug 24, 2021·Expert Opinion on Therapeutic Targets·David CabañeroRafael Maldonado

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