Perspectives on cavitation enhanced endothelial layer permeability

Colloids and Surfaces. B, Biointerfaces
Giovanna PeruzziCarlo Massimo Casciola

Abstract

Traditional drug delivery systems, where pharmaceutical agents are conveyed to the target tissue through the blood circulation, suffer of poor therapeutic efficiency and limited selectivity largely due to the low permeability of the highly specialised biological interface represented by the endothelial layer. Examples concern cancer therapeutics or degenerative disorders where drug delivery is inhibited by the blood-brain barrier (BBB). Microbubbles injected into the bloodstream undergo volume oscillations under localised ultrasound irradiation and possibly collapse near the site of interest, with no effect on the rest of the endothelium. The resulting mechanical action induces a transient increase of the inter-cellular spaces and facilitates drug extravasation. This approach, already pursed in in vivo animal models, is extremely expensive and time-consuming. On the other hand in vitro studies using different kinds of microfluidic networks are firmly established in the pharmaceutical industry for drug delivery testing. The combination of the in vitro approach with ultrasound used to control microbubbles oscillations is expected to provide crucial information for developing cavitation enhanced drug delivery protocols and for scr...Continue Reading

Citations

Jun 9, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xuechen QianAiguo Wu
Feb 23, 2020·Frontiers in Pharmacology·Xiaowen CaiChuanshan Xu
Jun 18, 2020·Pharmaceutics·Bahez GarebJos G W Kosterink
Apr 5, 2021·Ultrasound in Medicine & Biology·Cynthia D AndersonRalph V Shohet
Jul 3, 2021·Micromachines·Giulia GrisantiCarlo Massimo Casciola
Aug 25, 2021·Trends in Cancer·Janith WanigasekaraJames F Curtin
May 19, 2019·Ultrasonics Sonochemistry·Allison Loo Yong Kee, Boon Mian Teo
Oct 1, 2020·International Journal of Pharmaceutics·Tamotsu MaruyamaRyo Suzuki

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