Perspectives on fatigue from the study of chronic fatigue syndrome and related conditions.

PM & R : the Journal of Injury, Function, and Rehabilitation
Daniel J Clauw

Abstract

Fatigue is a symptom whose causes are protean and whose phenotype includes physical, mood, and behavioral components. Chronic fatigue syndrome (CFS) is an illness that has strong biological underpinnings and no definite etiology. Diagnostic criteria established by the Centers for Disease Control and Prevention have helped classify CFS as an overlap of mood, behavioral, and biological components. These include the presence of fatigue for more than 6 months associated with a diminution of functional activity and somatic symptoms, and pain not attributable to a specific diagnosis or disease. Four of the following criteria need to be present: sore throat, impaired memory or cognition, unrefreshing sleep, postexertional fatigue, tender glands, aching stiff muscles, joint pain, and headaches. Many researchers have observed that CFS shares features in common with other somatic syndromes, including irritable bowel syndrome, fibromyalgia, and temporomandibular joint dysfunction. Correlations between inflammation and infection, augmented sensory processing, abnormalities of neurotransmitters, nerve growth factors, low levels of serotonin and norepinephrine, abnormalities of homeostasis of the stress system, and autonomic dysfunction may ...Continue Reading

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Citations

Feb 11, 2016·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Jone Furlund OweOle-Bjørn Tysnes
Jul 27, 2010·PM & R : the Journal of Injury, Function, and Rehabilitation·Lynn H Gerber
Jul 27, 2010·PM & R : the Journal of Injury, Function, and Rehabilitation·Leonard A JasonNicole Porter
Jul 27, 2010·PM & R : the Journal of Injury, Function, and Rehabilitation·Basil A Eldadah
Jan 1, 2013·Journal of Psychosomatic Research·John W WarrenDaniel J Clauw
Feb 2, 2013·Korean journal of family medicine·So-Myung ChoiGo-Young Kim
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Aug 10, 2019·Diagnostics·Mateo Cortes RiveraBrett A Lidbury
May 23, 2014·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Philip J MeaseYong Wang

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