Perspectives on Gene Regulatory Network Evolution

Trends in Genetics : TIG
Marc S Halfon

Abstract

Animal development proceeds through the activity of genes and their cis-regulatory modules (CRMs) working together in sets of gene regulatory networks (GRNs). The emergence of species-specific traits and novel structures results from evolutionary changes in GRNs. Recent work in a wide variety of animal models, and particularly in insects, has started to reveal the modes and mechanisms of GRN evolution. I discuss here various aspects of GRN evolution and argue that developmental system drift (DSD), in which conserved phenotype is nevertheless a result of changed genetic interactions, should regularly be viewed from the perspective of GRN evolution. Advances in methods to discover related CRMs in diverse insect species, a critical requirement for detailed GRN characterization, are also described.

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Aug 11, 2018·Genesis : the Journal of Genetics and Development·Jorge Victor Wilfredo Cachay WesterNadia Monesi
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Apr 25, 2021·Trends in Genetics : TIG·Maud Fagny, Frédéric Austerlitz
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Aug 30, 2021·Evolution & Development·Carlos Espinosa-SotoYuridia S Posadas-García
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