PMID: 9541204Apr 16, 1998Paper

Perspectives on genetic aspects of dental patterning

European Journal of Oral Sciences
K M WeissC Shashikant

Abstract

Nearly a century of speculation and experimentation has gone into trying to understand the mechanisms that establish the pattern of the differentiated heterodont dentition. Regionally differing qualitative (combinatorial) expression of regulatory genes appears to be involved in this process. Work by our laboratory and others shows that the six members of the mammalian Dlx family of homeobox genes are expressed (a) at multiple times during dental development, (b) differently at different stages, (c) in a way that is related to their genomic organization as gene-pairs linked to three of the four Hox clusters of positional patterning genes. The expression appears to be involved in jaw regionalization, tooth initiation, and tooth development. However, this expression correlates with no single aspect of dental patterning or tooth development, involves redundant and complementary function, and developmental differences between the maxillary and mandibular dentition suggest that other elements remain to be identified. For example, the possibility that quantitative aspects of gene expression specify developmental fields in the dentition has not yet been investigated. Although the maxilla and mandible develop differently, indirect evide...Continue Reading

Citations

Mar 28, 2008·Journal of Cellular Physiology·Frédéric LézotAriane Berdal
Oct 8, 1999·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·A C Jones, M J Ford
Mar 8, 2000·Mechanisms of Development·J Jernvall, I Thesleff
May 20, 1999·Mechanisms of Development·J L DavideauA Berdal
Sep 7, 2012·Comparative and Functional Genomics·Chien-Hua PengChuan-Yi Tang
Jul 25, 2006·Proceedings of the National Academy of Sciences of the United States of America·Ran KafriYitzhak Pilpel
Aug 23, 2002·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·Pamela C Yelick, Thomas F Schilling
Nov 24, 1998·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·K M WeissZ Zhao
Apr 22, 2003·Archives of Histology and Cytology·Tatsuya ShibaguchiKojiro Kurisu
Nov 11, 2003·Orthodontics & Craniofacial Research·R J Radlanski
Apr 6, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·F LézotA Berdal
Jan 20, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·F LézotA Berdal
Oct 18, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·D W Stock
Aug 24, 2017·American Journal of Physical Anthropology·Christopher M StojanowskiDebbie Guatelli-Steinberg

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