Perspectives on Human Immunodeficiency Virus (HIV) Cure: HIV Persistence in Tissue

The Journal of Infectious Diseases
Eli A Boritz, Daniel C Douek

Abstract

The uneven anatomic distribution of cell subsets that harbor human immunodeficiency virus (HIV) during antiretroviral therapy (ART) complicates investigation of the barriers to HIV cure. Here we propose that while previous studies done largely in blood cells have led to important investigations into HIV latency, other important mechanisms of HIV persistence during ART may not be readily apparent in the bloodstream. We specifically consider as an example the question of ongoing HIV replication during ART. We discuss how growing understanding of key anatomic sanctuaries for the virus can inform future experiments aimed at further clarifying this issue.

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Jul 12, 2017·AIDS Research and Human Retroviruses·Rebecca RoseMichael S McGrath
Sep 7, 2017·Antimicrobial Agents and Chemotherapy·Edurne Garcia-VidalJosé A Esté
May 28, 2019·Cellular and Molecular Life Sciences : CMLS·Ivan Sadowski, Farhad B Hashemi
Jul 31, 2019·The Journal of Clinical Investigation·William R McManusMary F Kearney
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Nov 18, 2018·Gene Therapy·Lei ChenYu-Dong Cai
Sep 27, 2020·Scientific Reports·Mildred D PerezOlaf Kutsch

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