Perspectives on integration of cell extrinsic and cell intrinsic pathways of signaling required for differentiation of noradrenergic sympathetic ganglion neurons

Autonomic Neuroscience : Basic & Clinical
Anjali A Sarkar, Marthe J Howard

Abstract

This review presents an analysis of current research aimed at deciphering the interplay of cell extrinsic and intrinsic signals required for specification and differentiation of noradrenergic sympathetic ganglion neurons. The development of noradrenergic sympathetic ganglion neurons depends upon expression of a core set of DNA regulatory molecules, including the Phox2 homeodomain proteins and the basic helix-loop-helix proteins, HAND2 and MASH1 whose expression is dependent upon cell extrinsic cues. Both bone morphogenetic protein(s) and cAMP have an integral role in the specification/differentiation of noradrenergic sympathetic ganglion neurons but how signaling downstream of these molecules is integrated and identification of their particular functions is just beginning to be elucidated. Data currently available suggests a model with BMP providing both instructive and permissive cues in a pathway integrated by cAMP and MAPK by activation of both canonical and non-canonical intracellular signaling cascades.

References

Aug 1, 1995·Developmental Dynamics : an Official Publication of the American Association of Anatomists·J E VarleyG D Maxwell
Jan 1, 1993·Developmental Dynamics : an Official Publication of the American Association of Anatomists·M J Howard, M D Gershon
Sep 3, 1998·The Journal of Biological Chemistry·D J SwansonE J Lewis
Jul 3, 2002·Nature Reviews. Neuroscience·Nicolas BertrandFrançois Guillemot
Jul 3, 2002·Nature Reviews. Neuroscience·Christo Goridis, Hermann Rohrer
Dec 11, 2002·The Journal of Cell Biology·Lisette HariLukas Sommer
Jan 1, 2004·Drug News & Perspectives·Hermann Rohrer
Mar 23, 2004·Molecular and Cellular Neurosciences·Laura J Lewis-TuffinDona M Chikaraishi
Aug 27, 2004·Development·Konstantina TsarovinaHermann Rohrer
Nov 9, 2004·Current Opinion in Cell Biology·Maurice Kléber, Lukas Sommer
Dec 25, 2004·Developmental Biology·Marthe J Howard
Apr 20, 2005·The Journal of Cell Biology·Maurice KléberLukas Sommer
Jun 2, 2005·Cellular and Molecular Life Sciences : CMLS·F Ille, L Sommer
Sep 15, 2005·Journal of Neurochemistry·Marlene M HsiehElaine J Lewis
Sep 17, 2005·Developmental Biology·Hongbin LiuMarthe J Howard
Nov 11, 2005·Journal of Molecular Neuroscience : MN·Jennifer L RychlikElaine J Lewis
Dec 7, 2005·The Journal of Biological Chemistry·Chutamas BenjanirutOurania M Andrisani

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Citations

Jul 3, 2008·Journal of Molecular Neuroscience : MN·Adriane D Sumner, Joseph F Margiotta
Jan 19, 2011·Molecular and Cellular Neurosciences·Michael J PellegrinoBeth A Habecker
Sep 15, 2009·Autonomic Neuroscience : Basic & Clinical·Jason A Luther, Susan J Birren
Sep 29, 2009·Autonomic Neuroscience : Basic & Clinical·Uwe Ernsberger, Hermann Rohrer
Sep 8, 2009·Autonomic Neuroscience : Basic & Clinical·Galina Apostolova, Georg Dechant
May 22, 2007·Molecular and Cellular Neurosciences·Galina ApostolovaGeorg Dechant
Jul 16, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Damien ParlierEric J Bellefroid
Apr 14, 2009·Developmental Biology·Stine Büchmann-MøllerLukas Sommer
Nov 1, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Tyler J HendershotMarthe J Howard
Sep 23, 2014·Cellular and Molecular Neurobiology·Burkhard SchützEberhard Weihe

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