Perspectives on Nonalcoholic Fatty Liver Disease: An Overview of Present and Future Therapies

Journal of Clinical and Translational Hepatology
John VizueteJulio Gutierrez

Abstract

Nonalcoholic fatty liver disease (NAFLD) represents a major public health epidemic. Pharmacologic therapies for this condition are scarce, but multiple agents with novel mechanisms of action are in development. Here we review the pathophysiology and natural history of NALFD, diagnostic testing and data for currently available treatment strategies. We then turn our attention to promising developmental drugs and their respective trials. As the prevalence of fatty liver disease increases, clinicians will have more tools at hand for management of this condition. We conclude the horizon is bright for patients and doctors who deal with NAFLD.

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Citations

Apr 6, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Tianqi WangDong Zhang
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Dec 6, 2018·International Journal of Hepatology·Ayane A RodriguesDaniel F P Vasconcelos
Dec 22, 2019·Experimental Neurology·Matthew T Goodus, Dana M McTigue

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Methods Mentioned

BETA
biopsies
biopsy

Software Mentioned

FibroScan
CENTAUR

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