Perspectives on oral squamous cell carcinoma prevention-proliferation, position, progression and prediction

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
P J Thomson

Abstract

Squamous cell carcinoma arising from oral mucosal epithelium remains a lethal and deforming disease due to tumour invasion, oro-facial destruction, cervical lymph node metastasis and ultimate blood-borne dissemination. Worldwide, 300 000 new cases are seen each year, with a recent and significant rise in incidence affecting particularly the young. To rationalize perspectives on preventive strategies in oral cancer management, this study addresses a number of fundamental questions regarding carcinogenesis: proliferation-what epithelial cell changes precede tumour development? Position-why are certain oral sites so predisposed to cancer? Progression-why do some precursor lesions progress to invasive carcinoma and others do not? Prediction-how can we predict individual patient and/or lesion behaviour to prevent disease progression? By improving our understanding of oral carcinogenesis, can we thereby facilitate more effective primary, secondary and tertiary preventive strategies and ultimately reduce the global burden of oral squamous cell carcinoma (OSCC)?

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Citations

May 28, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Stefano BasilePierluigi Benedetti Panici
May 28, 2019·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Michaela L GoodsonPeter J Thomson
Jun 15, 2019·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Felipe Martins SilveiraManoela Domingues Martins
Sep 24, 2019·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Siu-Wai Choi, Peter Thomson
Feb 14, 2020·Anti-cancer Agents in Medicinal Chemistry·Isadora C SilveiraVirgínia O Crema
Mar 13, 2020·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Peter Thomson
Jan 7, 2020·Clinical Oral Investigations·Xiaoyu LinCanhua Jiang
Aug 3, 2020·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Chui S ChuSiu-Wai Choi
Aug 3, 2020·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·John AdeoyeSiu-Wai Choi
Sep 18, 2020·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Weilan WangSiu-Wai Choi
Dec 13, 2018·Journal of Immunology Research·Mircea TampaSimona Roxana Georgescu
May 10, 2019·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Siu-Wai Choi, Peter Thomson
Sep 13, 2018·International Journal of Molecular Sciences·Giuseppe TroianoGiuseppe Pannone
Jan 9, 2019·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Federica BaldanJelena Milasin
Nov 19, 2020·Cancer Management and Research·Hong-Yu Zhang, Jian-Hui Ma
Oct 27, 2020·Frontiers in Endocrinology·V Bharath KumarMu-Kuan Chen
Feb 27, 2021·Frontiers in Cell and Developmental Biology·Nádia Ghinelli AmôrAna Paula Campanelli
Apr 20, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yuanyuan LiJuan Xia
Nov 17, 2021·Clinical Oral Investigations·Humberto Jácome-SantosSérgio de Melo Alves-Junior

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