Perspectives on systolic hypertension. The Framingham study

Circulation
W B KannelD L McGee

Abstract

Diastolic hypertension has been widely and justifiably accepted as a cause of cardiovascular mortality. However, it has also been accepted that the cardiovascular sequelae of hypertension derive chiefly from the diastolic component. Because systolic and diastolic pressure are usually highly correlated it is not easy to dissociate the effects of each. Statistical analysis suggests that systolic pressure is actually the more potent contributor to cardiovascular sequelae. Even isolated systolic pressure elevation is associated witn an excess cardiovascular mortality. At low diastolic pressures (i.e., less than 95 mm Hg), risk rises with the level of systolic pressure. Also, isolated systolic hypertension is most ominous in the elderly, in whom it is highly prevalent. Isolated systolic hypertension was related to the occurrence of "direct" complications as well as to atherosclerotic sequelae. It was also associated with excess mortality, taking into account rigid vessels as judged from pulse-wave recordings. Trials to determine whether the treatment of isolated systolic hypertension is efficacious for avoiding its demonstrated excess cardiovascular morbidity and mortality are urgently needed.

References

Dec 1, 1976·International Journal of Epidemiology·T GordonW B Kannel
Jan 1, 1969·The American Journal of the Medical Sciences·E D FrohlichH P Dustan
Oct 19, 1972·The New England Journal of Medicine·W B KannelM Feinleib
Aug 30, 1973·The New England Journal of Medicine·J Koch-Weser
May 1, 1966·The American Journal of Cardiology·J H Moyer, A N Brest

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Citations

Apr 1, 1992·Cardiovascular Drugs and Therapy·M F Oliver
Jan 1, 1991·Cardiovascular Drugs and Therapy·G H Rutan
Jan 1, 1987·International Archives of Occupational and Environmental Health·G Schwaberger
Aug 1, 1986·Journal of Behavioral Medicine·J R EaglestonB Arnow
Dec 1, 1993·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·D A SclarM A Gill
Jul 31, 1998·Journal of Urban Health : Bulletin of the New York Academy of Medicine·L Breslow
Jan 1, 1990·Annals of Biomedical Engineering·F E Yates, L A Benton
Mar 1, 1987·Journal of General Internal Medicine·F A Lederle
Jun 1, 1992·Aging : Clinical and Experimental Research·A Fletcher, C Bulpitt
Nov 19, 2011·Lifetime Data Analysis·Yanyan LiuHaibo Zhou
Mar 20, 2003·Current Diabetes Reports·James M Galloway
Sep 10, 2002·Current Hypertension Reports·Carmine ZoccaliGiovanni Tripepi
Nov 1, 1983·Progress in Cardiovascular Diseases·A V Chobanian
Jan 1, 1992·Pharmacology & Therapeutics·G D Johnston
Jan 1, 1995·Archives of Gerontology and Geriatrics·R AntonicelliE Paciaroni
Jan 1, 1987·Social Science & Medicine·T OmuraI Shigematsu
Oct 1, 1988·Journal of the American College of Cardiology·R M Schieken
Mar 1, 1989·Journal of the American College of Cardiology·R KaramB P Healy
Sep 1, 1993·Journal of the American College of Cardiology·C J LavieA B Littman
Nov 2, 1995·The American Journal of Cardiology·V K RamanK Lindpaintner
Mar 14, 2000·Hearing Research·G A GatesR D'Agostino
Feb 1, 1991·Journal of the American College of Cardiology·A C PearsonA J Labovitz
Feb 1, 1991·Journal of the American College of Cardiology·R A Phillips
Feb 1, 1984·Journal of the American College of Cardiology·H SmulyanB Gribbin
Feb 1, 1985·Journal of the American College of Cardiology·L R KrakoffK Yeager
Aug 1, 1987·Journal of the American College of Cardiology·W B KannelP S Vokonas
Jun 1, 1997·Journal of the American College of Cardiology·H Smulyan, M E Safar
Dec 1, 1990·Baillière's Clinical Endocrinology and Metabolism·W Krone, D Müller-Wieland
Nov 17, 1983·The New England Journal of Medicine·J W Rowe
Dec 23, 1993·The New England Journal of Medicine·A SagieD Levy
Jan 1, 1990·Critical Reviews in Food Science and Nutrition·J W AndersonS E Whitis
May 14, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Fumiyoshi KasagiShoichiro Fujita

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