Perspectives on treatment options for mesial temporal lobe epilepsy with hippocampal sclerosis

Expert Opinion on Pharmacotherapy
Caterina PalleriaEmilio Russo

Abstract

Mesial temporal lobe epilepsy associated with hippocampal sclerosis (MTLE-HS) is a syndrome that is often refractory to drug treatment. The effects on specific syndromes are not currently available from the pre-marketing clinical development of new AEDs; this does not allow the prediction of whether new drugs will be more effective in the treatment of some patients. We have reviewed all the existing literature relevant to the understanding of a potential effectiveness in MTLE-HS patients for the latest AEDs, namely brivaracetam, eslicarbazepine, lacosamide, perampanel and retigabine also including the most relevant clinical data and a brief description of their pharmacological profile. Records were identified using predefined search criteria using electronic databases (e.g., PubMed, Cochrane Library Database of Systematic Reviews). Primary peer-reviewed articles published up to the 15 June 2015 were included. All the drugs considered have the potential to be effective in the treatment of MTLE-HS; in fact, they possess proven efficacy in animal models; currently considered valuable tools for predicting drug efficacy in TLE. Furthermore, for some of these (e.g., lacosamide and eslicarbazepine) data are already available from post...Continue Reading

References

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Citations

Mar 21, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Lia SantulliSalvatore Striano
Apr 3, 2016·Clinical Neurology and Neurosurgery·Igor KuzmanovskiRozalinda Isjanovska
Apr 7, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Rita CitraroGiovambattista De Sarro
Apr 12, 2016·Epilepsy & Behavior : E&B·Giuseppe BorzìAngelo Labate
Apr 18, 2018·Epilepsia·Antonio LeoStefano Meletti
Oct 13, 2017·Expert Opinion on Pharmacotherapy·Carlo Di BonaventuraEmilio Russo
Nov 8, 2018·Expert Opinion on Pharmacotherapy·Alessandra MoranoCarlo Di Bonaventura
Jul 6, 2020·Biomedizinische Technik. Biomedical Engineering·Pegah KhosropanahVairavan Narayanan
Jan 19, 2021·Epilepsy & Behavior Reports·Annacarmen NiloMariarosaria Valente

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