PMID: 3768166Aug 1, 1986Paper

Persulfide sulfur is a growth factor for cells defective in sulfur metabolism

Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire
John I Toohey

Abstract

Several systems which generate persulfide sulfur promote in vitro proliferation of L1210 murine lymphoma cells. The systems include cysteine disulfides and pyridoxal, cystamine and diamine oxidase, beta-mercaptoalcohol disulfides and an alcohol dehydrogenase, and sulfide-treated proteins and a thiol. Persulfide sulfur is very unstable at pH near 7 and an essential feature of the growth-supporting systems is the ability to generate persulfide sulfur at a very low rate for long periods of time. Methyl disulfides (R--S--S--CH3) also support growth of L1210 cells and are more stable than persulfides (R--S--S--H). The requirement for these sulfur groups by L1210 cells may be related to the fact that these cells are defective in at least two enzymes of sulfur metabolism, cystathionase and 5'-methylthioadenosine phosphorylase. These findings provide the first evidence that persulfide sulfur may have a physiological role.

Citations

Nov 6, 2009·AIDS Research and Human Retroviruses·John I Toohey
Jun 21, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·John I Toohey
Dec 24, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Maria WróbelBolesław Papla
Aug 26, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·John I Toohey, Arthur J L Cooper
Aug 5, 2014·The Journal of Reproduction and Development·Robert E Click
Oct 30, 2012·Biochemical Pharmacology·Khosrow Kashfi, Kenneth R Olson
Jun 15, 2007·European Journal of Pharmacology·Małgorzata IciekLidia Włodek
Jul 12, 2008·The FEBS Journal·Renato SabelliSonia Melino
Mar 12, 2011·Cell Biology International·Stephen D BirdRobert J Walker
Feb 10, 2011·Analytical Biochemistry·John I Toohey
Jul 16, 2013·Nitric Oxide : Biology and Chemistry·Qian Li, Jack R Lancaster
Apr 6, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·John I Toohey
Mar 1, 2019·Antioxidants·Dayana BenchoamBeatriz Alvarez
Nov 7, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Min GaoLingxin Chen
Feb 15, 2020·Journal of the American Chemical Society·Vinayak S KhodadeJohn P Toscano

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