Persulfide synthases that are functionally coupled with translation mediate sulfur respiration in mammalian cells

British Journal of Pharmacology
Shigemoto FujiiTakaaki Akaike

Abstract

Cysteine persulfide and polysulfide are produced in cells and exist in abundance in both low MW and protein fractions. However, the mechanism of regulation of the formation of cellular cysteine polysulfides and the physiological functions of cysteine persulfides/polysulfides produced in cells are not fully understood. We recently demonstrated that cysteinyl-tRNA synthetase (CARS) is a novel cysteine persulfide synthase. CARS is involved in protein polysulfidation that is coupled with translation. In particular, mitochondria function in biogenesis and bioenergetics is also supported and up-regulated by cysteine persulfide derived from mitochondrial CARS (also known as CARS2). Here, we provide an overview of recent advances in reactive persulfide research and our understanding of the mechanisms underlying the formation and the physiological roles of reactive persufides, with a primary focus on the formation of cysteine persulfide by CARS and the most fundamental mitochondrial bioenergetics mediated by persulfides, that is, sulfur respiration. LINKED ARTICLES: This article is part of a themed section on Chemical Biology of Reactive Sulfur Species. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/...Continue Reading

References

Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J S BeckmanB A Freeman
Apr 29, 1998·Annual Review of Physiology·M K Grieshaber, S Völkel
Mar 8, 2000·Microbiology and Molecular Biology Reviews : MMBR·C R WoeseD Söll
Oct 6, 2000·The American Journal of Medicine·A van der Vliet, C E Cross
Sep 18, 2002·The Journal of Biological Chemistry·Hiromi SasakiShiro Bannai
Mar 29, 2003·Journal of Molecular Biology·Chun-Mei ZhangYa-Ming Hou
Apr 21, 2004·Protein Science : a Publication of the Protein Society·Mitchel D de BeusWilfredo Colón
Jul 9, 2004·American Journal of Physiology. Cell Physiology·Henry Jay FormanMartine Torres
Feb 23, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Marc GoubernFrédéric Bouillaud
Oct 2, 2007·Nature Chemical Biology·Tomohiro SawaTakaaki Akaike
Oct 25, 2007·Biochemical Society Transactions·B Halliwell
Dec 7, 2007·Chemical Research in Toxicology·Koji Uchida, Takahiro Shibata
Oct 3, 2009·Science Signaling·Tanja K Rudolph, Bruce A Freeman
Nov 12, 2009·Science Signaling·Asif K MustafaSolomon H Snyder
Aug 12, 2010·Nature Reviews. Molecular Cell Biology·Min GuoPaul Schimmel
Feb 10, 2011·Analytical Biochemistry·John I Toohey
Sep 21, 2011·Chemical Reviews·Francisco J SchopferBruce A Freeman
Jan 11, 2012·Proceedings of the National Academy of Sciences of the United States of America·Takayuki MorikawaMakoto Suematsu
Jul 10, 2012·Nature Chemical Biology·Motohiro NishidaTakaaki Akaike
Mar 29, 2013·Nature Communications·M Scott VandiverSolomon H Snyder
Jun 14, 2013·Antioxidants & Redox Signaling·Kazuhiro ShirozuFumito Ichinose
Aug 3, 2013·Cold Spring Harbor Perspectives in Biology·Oliver Stehling, Roland Lill
Feb 12, 2014·The Journal of Biological Chemistry·Helmut Sies
Apr 16, 2014·Proceedings of the National Academy of Sciences of the United States of America·Tomoaki IdaTakaaki Akaike
Mar 6, 2015·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Shintaro NakanoMakoto Suematsu
Oct 11, 2015·Free Radical Biology & Medicine·Artur P JaroszBulent Mutus
Dec 17, 2015·Journal of the American Chemical Society·Pramod K YadavRuma Banerjee
Aug 29, 2016·Nucleic Acids Research·Nozomu TakahashiKazuhito Tomizawa
Oct 30, 2016·Biochemical and Biophysical Research Communications·Minkyung JungTakaaki Akaike
Dec 17, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shingo KasamatsuTakaaki Akaike
Feb 16, 2017·Proceedings of the National Academy of Sciences of the United States of America·Takayuki ShimizuShinji Masuda
Jul 21, 2017·Thorax·Tadahisa NumakuraMasakazu Ichinose

❮ Previous
Next ❯

Citations

Feb 27, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kenneth R OlsonKarl D Straubg
Mar 7, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Gopi K KolluruChristopher G Kevil
Jun 27, 2020·Antioxidants & Redox Signaling·Kenneth R Olson
Jan 27, 2019·British Journal of Pharmacology·Péter NagyStanislav Kopriva
Jun 17, 2020·Antioxidants & Redox Signaling·Shingo Kasamatsu
Nov 18, 2020·Antioxidants & Redox Signaling·Shingo KasamatsuTakaaki Akaike
Nov 3, 2020·Redox Biology·Bindu D PaulKhosrow Kashfi
Feb 5, 2021·Journal of Clinical Biochemistry and Nutrition·Tianli ZhangTomohiro Sawa
Feb 21, 2021·The Journal of Biological Chemistry·Anna MoselerJérémy Couturier
May 27, 2021·Nature Communications·Eizo MarutaniFumito Ichinose
Nov 18, 2021·The Journal of International Medical Research·Hironori FukuokaItaru Endo
Jan 4, 2022·Antioxidants & Redox Signaling·Maria PeleliAndreas Papapetropoulos

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.