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Perturbation biology models predict c-Myc as an effective co-target in RAF inhibitor resistant melanoma cells

bioRxiv

Aug 21, 2014

Anil KorkutChris Sander

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Abstract

Systematic prediction of cellular response to perturbations is a central challenge in biology, both for mechanistic explanations and for the design of effective therapeutic interventions. We addressed this challenge using a computational/experimental method, termed perturbation biology,...read more

Mentioned in this Paper

Melanoma Pathway
BRAF protein, human
MYC wt Allele
Simulation
Toxic Epidermal Necrolysis
Resistance Process
Melanoma
MYC gene
Computational Technique
Melanoma vaccine
6
8
Paper Details
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  • Perturbation biology models predict c-Myc as an effective co-target in RAF inhibitor resistant melanoma cells

    bioRxiv

    Aug 21, 2014

    Anil KorkutChris Sander

    PMID: 990008201

    DOI: 10.1101/008201

    Abstract

    Systematic prediction of cellular response to perturbations is a central challenge in biology, both for mechanistic explanations and for the design of effective therapeutic interventions. We addressed this challenge using a computational/experimental method, termed perturbation biology,...read more

    Mentioned in this Paper

    Melanoma Pathway
    BRAF protein, human
    MYC wt Allele
    Simulation
    Toxic Epidermal Necrolysis
    6
    8
    Paper Details
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