Perturbation of artificial and biological membranes by organic compounds of aliphatic, alicyclic and aromatic structure

Toxicology in Vitro : an International Journal Published in Association with BIBRA
M EngelkeL Vaalavirta

Abstract

Aliphatic, alicyclic and aromatic hydrocarbons interact with biological membranes. Until now little has been known about their mode of interaction with the membrane bilayer and membrane integral proteins with toxic effects to cells. The lipid theory hypothesis explains the toxic effects by the organic solvent-induced disorder in the lipid bilayer, which indirectly affects the function of membrane-embedded proteins. The extent of bilayer perturbations is ascribed to the solvent accumulation in the bilayer, which is related only to the lipophilicity of the molecule, independent of the chemical structure. In this study the fluidizing effects of aliphatic, alicyclic and aromatic hydrocarbons were compared. Membrane fluidity changes were estimated from the pyrene excimer formation, using pyrene and pyrene derivatives to label specifically the localization of solvent molecules in the transverse plane of the bilayer. Liposomal, microsomal and synaptosomal membrane preparations were evaluated because proteins and cholesterol, as natural membrane components, increase the bilayer order and reduce the organic solvent membrane/buffer partition. In the concentration range investigated, only the aromatic solvents disorder the lipid bilayer, ...Continue Reading

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Citations

Mar 11, 2011·Journal of Toxicology and Environmental Health. Part a·Pål A OlsvikSonnich Meier
Mar 9, 2007·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Sonnich MeierHolm Holmsen
Oct 19, 2006·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Catherine McDermottJames J A Heffron
Jan 24, 2007·Toxicology and Applied Pharmacology·Catherine McDermottJames J A Heffron
Dec 17, 2009·The American Journal of Forensic Medicine and Pathology·Antonina ArgoPaolo Procaccianti
Oct 10, 2002·American Journal of Physiology. Cell Physiology·Joachim Gartzke, Klaus Lange
Jul 10, 2001·American Journal of Physiology. Cell Physiology·K Lange, J Gartzke
Apr 10, 2019·Applied Microbiology and Biotechnology·Daniel P BrinkMarie F Gorwa-Grauslund

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