Perturbation of gut microbiota decreases susceptibility but does not modulate ongoing autoimmune neurological disease.

Journal of Neuroinflammation
Clemens GödelGurumoorthy Krishnamoorthy

Abstract

The gut microbiota regulates the host immune and nervous systems and plays an important role in the pathogenesis of autoimmune neurological disease multiple sclerosis (MS). There are considerable efforts currently being undertaken to develop therapies for MS based on the modulation of microbiota. Evidence from experimental models suggests that the manipulation of microbiota through diet or antibiotics prior to the disease development limits disease susceptibility. However, it is currently unclear if microbiota manipulation therapies would also have an impact on ongoing neurological disease. Here, we examined the effect of antibiotic-based microbiota modulation in spontaneous experimental autoimmune encephalomyelitis (EAE) mouse models of MS before and after the onset of autoimmune disease. Prophylactic antibiotic treatment led to a significant reduction of susceptibility to spontaneous EAE. In contrast, antibiotic treatment after the onset of spontaneous EAE did not show a significant amelioration. These results reveal that the perturbation of gut bacteria alters disease susceptibility but has minimal impact on the ongoing neurological disease.

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Citations

May 2, 2020·International Journal of Molecular Sciences·Samiksha WasnikXiaolei Tang
Aug 28, 2020·Frontiers in Immunology·Josephine BrownLaurence Morel
Oct 13, 2020·Der Nervenarzt·L A GerdesA Peters
Dec 29, 2020·Frontiers in Immunology·Andrina RutschFrancesca Ronchi
Apr 4, 2021·International Journal of Molecular Sciences·Sameeksha ChopraAntoine Dufour
Apr 30, 2021·Frontiers in Immunology·Đorđe MiljkovićMirjana Dimitrijević
May 29, 2021·Multiple Sclerosis : Clinical and Laboratory Research·Christopher E McMurran
Jul 29, 2021·Immunology Letters·Đorđe MiljkovićVladimir P Badovinac
Sep 7, 2021·Acta Neuropathologica·Marjan GharagozlooPeter A Calabresi

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Methods Mentioned

BETA
flow cytometry
FACS
PMA
PCR
amplicon sequencing

Software Mentioned

GraphPad Prism
FlowJo TreeStar

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