Perturbation of natural killer cell function and receptors during HIV infection

Trends in Microbiology
Karla A Eger, Derya Unutmaz

Abstract

Natural killer (NK) cells play an important role in innate host defenses against a variety of pathogens. A recent report described striking perturbations in the expression of NK cell inhibitory and activating receptors in viremic human immunodeficiency virus (HIV)-infected patients, leading to functional abnormalities in these cells. This finding provides a mechanistic insight into NK cell dysfunction and its possible contribution to the impairment of innate host defenses in HIV-infected individuals.

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Citations

Jan 4, 2008·The Journal of Infectious Diseases·Jakob MichaëlssonDouglas F Nixon
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