Abstract
Women are advised not to attempt pregnancy while on hydroxyurea (HU) due to the teratogenic effects of this agent, based on results obtained from animal studies. Several case reports suggest that HU may have minimal or no teratogenic effects on the developing human fetus. Fourteen cases of HU therapy in pregnant patients diagnosed with acute or chronic myelogenous leukemia, primary thrombocythemia, or sickle cell disease (SCD) have been reported. Three pregnancies were terminated by elective abortion; 1 woman developed eclampsia and delivered a phenotypically normal stillborn infant. All other patients delivered live, healthy infants without congenital anomalies. We contend that case studies such as these have too few patients and cannot effectively address the adverse effect of HU on preimplantation embryo or fetuses. The objective of this study was to assess the risks associated with a clinically relevant dose of HU used for the treatment of SCD, on ovulation rate and embryo development, using adult C57BL/6J female mice as a model. In Experiment 1, adult female mice were randomly assigned to a treatment or a control group (N = 20/group). Treatment consisted of oral HU (30 mg/kg) for 28 days; while control mice received saline...Continue Reading
References
May 1, 1987·Biology of Reproduction·L J SpicerH A Tucker
Jun 1, 1985·Biology of Reproduction·J E Fortune, W Hansel
Dec 1, 1982·Endocrinology·J J Ireland, J F Roche
Sep 1, 1984·Journal of Reproduction and Fertility·K P McNattyD C Thurley
Oct 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·W Y GaoF Lori
Apr 27, 1995·The New England Journal of Medicine·S CortelazzoT Barbui
Apr 15, 1996·Genes & Development·S P LinkeG M Wahl
Apr 1, 1999·The New England Journal of Medicine·M H Steinberg
Dec 22, 1999·Pharmacotherapy·D C ByrdC K Alexander
Sep 9, 2000·Experimental Gerontology·E J YeoS C Park
Jun 16, 2001·Chemotherapy·W E IyamuT Asakura
Oct 29, 2002·Reproductive Toxicology·Anthony E ArchibongAlfred M Nyanda
Dec 8, 2004·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Gye Hyeong WooKunio Doi
Mar 18, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jin Yan, Barbara F Hales
Jan 11, 2008·AIDS Research and Human Retroviruses·Rahul P BakshiCharles Flexner
Feb 14, 2009·Annals of Hematology·Domenica CaramazzaSergio Siragusa
May 15, 2009·International Journal of Environmental Research and Public Health·Kea M JonesAnthony E Archibong
Aug 18, 2009·Environmental Research·Ibrahim Chahoud, Francisco J R Paumgartten
Citations
Jul 13, 2016·Neurotoxicity Research·Joaquín MartíJosé P Hervás
Jul 27, 2017·Neurotoxicity Research·Lucía Rodríguez-Vázquez, Joaquín Martí
Aug 15, 2019·Neurotoxicity Research·Vanessa MolinaJoaquín Martí
Jul 28, 2020·British Journal of Haematology·Lydia H PeckerSophie Lanzkron
Dec 14, 2018·International Journal of Molecular Sciences·Lucía Rodríguez-Vázquez, Joaquín Martí
Oct 3, 2018·Neurotoxicity Research·Lucía Rodríguez-VázquezJoaquín Martí
Dec 5, 2020·Journal of Clinical Medicine·Donovan A ArguetaKalpna Gupta
Apr 13, 2021·Bioscience Reports·Wei GaoXianfeng Yu
Jul 8, 2021·British Journal of Haematology·Lydia H PeckerKim Smith-Whitley