Perturbed T cell IL-7 receptor signaling in chronic Chagas disease

The Journal of Immunology : Official Journal of the American Association of Immunologists
María Cecilia AlbaredaSusana Adriana Laucella

Abstract

We have previously demonstrated that immune responses in subjects with chronic Trypanosoma cruzi infection display features common to other persistent infections with signs of T cell exhaustion. Alterations in cytokine receptor signal transduction have emerged as one of the cell-intrinsic mechanisms of T cell exhaustion. In this study, we performed an analysis of the expression of IL-7R components (CD127 and CD132) on CD4(+) and CD8(+) T cells and evaluated IL-7-dependent signaling events in patients at different clinical stages of chronic chagasic heart disease. Subjects with no signs of cardiac disease showed a decrease in CD127(+)CD132(+) cells and a reciprocal gain of CD127(-)CD132(+) in CD8(+) and CD4(+) T cells compared with either patients exhibiting heart enlargement or uninfected controls. T. cruzi infection, in vitro, was able to stimulate the downregulation of CD127 and the upregulation of CD132 on T cells. IL-7-induced phosphorylation of STAT5 as well as Bcl-2 and CD25 expression were lower in T. cruzi-infected subjects compared with uninfected controls. The serum levels of IL-7 were also increased in chronic chagasic patients. The present study highlights perturbed IL-7/IL-7R T cell signaling through STAT5 as a pot...Continue Reading

References

Apr 1, 1994·International Immunology·W O DutraJ C Parra
Jan 1, 1996·Scandinavian Journal of Immunology·W O DutraD G Colley
May 23, 1998·Annual Review of Immunology·W J Leonard, J J O'Shea
Apr 27, 2000·Molecular Immunology·K Imada, W J Leonard
Jun 22, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·L BaniJ Thèze
Oct 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·E John WherryRafi Ahmed
Jan 25, 2006·International Immunology·María Cecilia AlbaredaMiriam Postan
Oct 24, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Lucy Golden-MasonHugo R Rosen
Apr 17, 2007·Current Opinion in Immunology·Onur BoymanJonathan Sprent
Jun 26, 2007·Nature Reviews. Immunology·Peter H KrammerInna N Lavrik
Jul 24, 2007·Current Opinion in Immunology·David HildemanPhilippa Marrack
Jul 28, 2007·Current Opinion in Immunology·Haina Shin, E John Wherry
Jul 31, 2007·Archivum Immunologiae Et Therapiae Experimentalis·Jeremy A RossRobert A Kirken
Apr 9, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anmol ChandeleSusan M Kaech
May 6, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marc SchwenekerJoseph M McCune
Jul 17, 2008·Immunologic Research·Timothy W Hand, Susan M Kaech
Aug 8, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lisa M Bixby, Rick L Tarleton
Apr 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sara L ColpittsPhillip Scott
Jul 15, 2009·Cell·Herbert W VirginRafi Ahmed
Aug 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·María Cecilia AlbaredaMiriam Postan
Nov 3, 2009·Cytokine·Lisa Colleen Osborne, Ninan Abraham
Nov 26, 2009·Acta Tropica·Gabriel A Schmunis, Zaida E Yadon
May 5, 2010·The American Journal of Tropical Medicine and Hygiene·María Cecilia AlbaredaMiriam Postan
Sep 13, 2011·PLoS Neglected Tropical Diseases·Rodolfo ViottiSusana Laucella

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Citations

Oct 13, 2018·Cells·Milton O AguileraMaría I Colombo
Oct 15, 2019·Trends in Parasitology·Eva V Acosta RodríguezAdriana Gruppi
Mar 23, 2021·Scientific Reports·Magalí C GirardKarina A Gómez
Feb 5, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Desiré Casares-MarfilMarialbert Acosta-Herrera
Jun 2, 2021·PLoS Neglected Tropical Diseases·María Ailén NataleSusana Adriana Laucella
May 3, 2021·American Journal of Reproductive Immunology : AJRI·Theresa VilsmaierThomas Kolben
May 22, 2021·Transplant Immunology·Jian LuFeng Qi

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