Pertussis in infants under one year old: risk markers and vaccination status--a case-control study

Vaccine
C Stein ZamirH Shoob

Abstract

Pertussis is a contagious bacterial disease causing substantial health burden. Pertussis-related morbidity and mortality are highest in young infants. We investigated risk markers for pertussis and vaccination status in infants. Reported pertussis cases under one year old during 1998-2011 in the Jerusalem district were matched to controls by birthdate and residence. Data sources included epidemiological investigations, health records and vaccination records (number and dates of DTP\DTaP doses scheduled at 2, 4, 6 months). Vaccine effectiveness was calculated by number of vaccine doses stratified by age group. Timeliness of vaccine doses was also evaluated. The study population included 1268 infants under 1 year: 317 pertussis cases and 951 age-matched controls (mean age 3.95±3, median 2.9 months). Low birthweight (<2500g, 12.3% in cases vs. 6.3% in controls) and high birth order (4th and above) were found to be independent risk markers. Male gender and low socio-economic status were more frequent among cases. Some 40% of the cases (127/317) were hospitalized, most of them (111/127, 87.4%) were under 4 months (mean age 2.42±2.05, median 1.8 months). The distribution of the number of pertussis vaccine doses 0, 1, 2 and 3 differed...Continue Reading

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Citations

Jul 12, 2017·Human Vaccines & Immunotherapeutics·Chen Stein-Zamir, Avi Israeli
Jan 12, 2017·Journal of the Pediatric Infectious Diseases Society·Michelle M HughesJoanne Katz
Jul 19, 2019·Vaccines·Hannah ChisholmHelen Petousis-Harris
Oct 31, 2019·BMC Infectious Diseases·Nicoline A T van der MaasHester E de Melker
Apr 14, 2017·The Pediatric Infectious Disease Journal·Øystein Rolandsen RiiseJann Storsæter
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Nov 5, 2019·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Federica BrosioGiovanni Gabutti

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