PMID: 2505200Jul 3, 1989Paper

Pertussis toxin treatment counteracts the cardiovascular effects of neuropeptide Y and clonidine in the awake unrestrained rat

Neuroscience Letters
K FuxeL F Agnati

Abstract

The role of G-proteins in the mediation of the cardiovascular effects of neuropeptide Y and the alpha 2-adrenoceptor agonist clonidine was investigated by injections of pertussis toxin (10 micrograms/30 microliters, i.v.t., 24 h) in the awake unrestrained male rat. Treatment with pertussis toxin was found to inhibit the hypotensive and bradycardic actions of neuropeptide Y (1250 pmol) and the hypotensive actions of clonidine (1875 pmol). Control experiments showed that treatment with pertussis toxin caused an approximately 50% reduction in the back-ADP-ribosylation of GTP-binding proteins. These results suggest that G-proteins mediate the central cardiovascular actions of neuropeptide Y and clonidine.

References

Mar 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·W S Young, M J Kuhar
May 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·T Katada, M Ui

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Citations

Jan 1, 1992·Progress in Neurobiology·Y DumontR Quirion
Jan 1, 1990·Annals of the New York Academy of Sciences·C WahlestedtD J Reis
Dec 3, 2010·Journal of Cell Science·Jean-Pierre VilardagaFrancisco Ciruela
Jun 25, 2016·Journal of Molecular Neuroscience : MN·Nora FurediErika Petervari
Jan 1, 1990·Annals of the New York Academy of Sciences·P IllesW Nörenberg
Apr 1, 1992·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·M Martire, G Pistritto

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