Pertussis vaccination strategies for neonates--an exploratory cost-effectiveness analysis

Vaccine
P A Scuffham, Peter McIntyre

Abstract

Hospitalisation and death from pertussis in highly immunised populations largely occurs before the first vaccination at 2 months. A Markov model was constructed to estimate the costs and health consequences of three strategies to reduce pertussis over the first 6 months of an infant's life. Earlier vaccination (at either birth or 1 month in addition to current practice) or vaccination of the parents soon after birth was compared with the current practice of vaccination at 2, 4 and 6 months. The model was populated using data on the incidence and costs from Australia. Disability-adjusted life-years (DALYs) were used as the primary outcome measure. The cost to the Australian public health system was chosen as the economic perspective, and Monte-Carlo simulations were used to accommodate uncertainties in the variables. Vaccination at birth was estimated to cost (S.D.) an additional A$33.21 (A$1.60) per infant and to reduce cases, deaths and DALYs by 45%. Vaccination at 1 month was estimated to cost an additional A$43.24 (A$8.98) per infant and to reduce morbidity by approximately 25%. Parental vaccination at birth was the most expensive alternative, costing an additional A$73.38 (A$4.98) per infant and reducing pertussis morbidity...Continue Reading

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Citations

Jul 3, 2007·New South Wales Public Health Bulletin·Kerri A VineySue Campbell-Lloyd
May 7, 2005·The Pediatric Infectious Disease Journal·J Jaime CaroEvelinda Trindade
May 7, 2005·The Pediatric Infectious Disease Journal·J Jaime CaroJudith A O'Brien
Mar 28, 2013·BMC Infectious Diseases·Elena ChiappiniMaurizio de Martino
Jan 28, 2012·Expert Review of Pharmacoeconomics & Outcomes Research·Aurelie MillierSibilia Quilici
Jan 26, 2010·Vaccine·Olivia J WhitePatrick G Holt
Dec 9, 2009·Advances in Pediatrics·Ayesha Mirza, Mobeen H Rathore
Jun 1, 2005·Pediatric Clinics of North America·Amanda C CohnLarry K Pickering
Jun 13, 2006·Lancet·Natasha S Crowcroft, Richard G Pebody
May 18, 2018·Human Vaccines & Immunotherapeutics·Laure-Anne Van BellinghenNadia Demarteau
Aug 18, 2018·Human Vaccines & Immunotherapeutics·Eder Gatti FernandesHillegonda Maria Dutilh Novaes
Nov 17, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anne-Sophie DebrieCamille Locht

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