PMID: 9437430Jan 23, 1998Paper

Pervasive conformational fluctuations on microsecond time scales in a fibronectin type III domain

Nature Structural Biology
Mikael AkkeA G Palmer

Abstract

A novel off-resonance rotating-frame 15N NMR spin relaxation experiment is used to characterize conformational fluctuations with correlation times between 32 and 175 microseconds in the third fibronectin type III domain of human tenascin-C. Conformational fluctuations of contiguous regions of the beta-sandwich structure of the type III domain may represent collective motions, such as transient twisting or breathing of the beta-sheets. Flexibility of the loop containing the Arg-Gly-Asp (RGD) tripeptide may affect the accessibility of this motif in protein-protein interactions.

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