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Pervasive cryptic epistasis in molecular evolution

PLoS Genetics

Oct 27, 2010

Mark LunzerAntony M Dean

Abstract

The functional effects of most amino acid replacements accumulated during molecular evolution are unknown, because most are not observed naturally and the possible combinations are too numerous. We created 168 single mutations in wild-type Escherichia coli isopropymalate dehydrogenase (...read more

Mentioned in this Paper

Vertebrates
Muscle Rigidity
CFC1 gene
Bacterial Proteins
Pseudomonas aeruginosa (antigen)
Alkalescens-Dispar Group
Genome
Enzymes, antithrombotic
Agar
Affect (Mental Function)
1
194
1
Paper Details
References
  • References98
  • Citations76
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Pervasive cryptic epistasis in molecular evolution

PLoS Genetics

Oct 27, 2010

Mark LunzerAntony M Dean

PMID: 20975933

DOI: 10.1371/journal.pgen.1001162

Abstract

The functional effects of most amino acid replacements accumulated during molecular evolution are unknown, because most are not observed naturally and the possible combinations are too numerous. We created 168 single mutations in wild-type Escherichia coli isopropymalate dehydrogenase (...read more

Mentioned in this Paper

Vertebrates
Muscle Rigidity
CFC1 gene
Bacterial Proteins
Pseudomonas aeruginosa (antigen)
Alkalescens-Dispar Group
Genome
Enzymes, antithrombotic
Agar
Affect (Mental Function)
1
194
1

Similar Papers Found In These Feeds

Paper Details
References
  • References98
  • Citations76
12345...
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